Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 4/20 | 0.51 |
| ▸ | CCR2 | P41597 | 8/20 | 0.49 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7082969 | 0.87 | ABCB11 (0.46) | ABCB11CCR2PTGER4S1PR3MAPT | |
| SCHEMBL6599182 | 0.81 | ABCB11 (0.73) | ABCB11CCR2 | |
| SCHEMBL7086963 | 0.80 | ABCB11 (0.55) | ABCB11CCR2MAPTPKMKDM4E | |
| SCHEMBL7089675 | 0.79 | ABCB11 (0.48) | ABCB11CCR2S1PR3MAPTPKM | |
| SCHEMBL7084277 | 0.78 | ABCB11 (0.63) | ABCB11CCR2 | |
| SCHEMBL7088120 | 0.77 | ABCB11 (0.74) | ABCB11CCR2PPARG | |
| SCHEMBL7083775 | 0.76 | ABCB11 (0.78) | ABCB11CCR2MAPTPKMKDM4E | |
| SCHEMBL7089748 | 0.73 | GAA (0.41) | ABCB11MAPTPKMKDM4EPPARG | |
| SCHEMBL7089579 | 0.73 | MAPT (0.57) | CCR2MAPTKDM4EPPARGMEN1 | |
| SCHEMBL6307041 | 0.73 | CCR2 (0.72) | ABCB11CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030144339-A1 | Indole derivatives as mcp-1 receptor antagonists | ASTRAZENECA AB (SE) | 2003-07-31 | — | — | US | claimed |
| CN-1395565-A | Indole derivatives as MCP-1 receptor antagonists | ASTRAZENECA AB (SE) | 2003-02-05 | — | — | CN | claimed |
| EP-1252142-A1 | INDOLE DERIVATIVES AS MCP-1 RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2002-10-30 | — | — | EP | claimed |
| WO-2001051466-A1 | INDOLE DERIVATIVES AS MCP-1 RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2001-07-19 | — | — | WO | claimed |
| US-20030144339-A1 | Indole derivatives as mcp-1 receptor antagonists | ASTRAZENECA AB (SE) | 2003-07-31 | — | — | US | disclosed |
| CN-1395565-A | Indole derivatives as MCP-1 receptor antagonists | ASTRAZENECA AB (SE) | 2003-02-05 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030144339-A1 | Indole derivatives as mcp-1 receptor antagonists | CCR2, CCR1, CCR5 | ABCB11 391/4885CCR2 1/4885PTGER4 503/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.