Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.49 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.49 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.47 |
| ▸ | FABP3 | P05413 | 1/20 | 0.46 |
| ▸ | FABP4 | P15090 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5342329 | 0.87 | SMN1; SMN2 (0.84) | SMN1; SMN2KDM4ECYP1A2CYP2D6CYP2C19 | |
| SCHEMBL9723737 | 0.84 | BACE1 (0.56) | SMN1; SMN2KDM4EGAAPOLBBACE1 | |
| SCHEMBL5311021 | 0.84 | KDM4E (0.82) | SMN1; SMN2KDM4ECYP1A2CYP2D6CYP2C19 | |
| SCHEMBL8335877 | 0.83 | ALDH1A1 (0.63) | SMN1; SMN2KDM4ECYP1A2CYP2D6CYP2C19 | |
| SCHEMBL8333549 | 0.81 | ALDH1A1 (0.68) | SMN1; SMN2KDM4ECYP1A2CYP2D6CYP2C19 | |
| SCHEMBL4131227 | 0.80 | GAA (0.57) | SMN1; SMN2KDM4ECYP1A2CYP2D6CYP2C19 | |
| SCHEMBL7894667 | 0.79 | GAA (0.57) | KDM4EGAAPOLBTAS1R3TAS1R1 | |
| SCHEMBL8333686 | 0.79 | SMN1; SMN2 (0.57) | SMN1; SMN2KDM4ECYP1A2CYP2D6CYP2C19 | |
| SCHEMBL8340026 | 0.79 | CYP2C8 (0.71) | SMN1; SMN2KDM4ECYP1A2CYP2D6CYP2C19 | |
| SCHEMBL7079259 | 0.78 | HDAC7 (0.57) | SMN1; SMN2KDM4EALDH1A1FABP3FABP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326835-A1 | BENZAMIDE COMPOUNDS AS APO B SECRETION INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002028835-A1 | BENZAMIDE COMPOUNDS AS APO B SECRETION INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-04-11 | — | — | WO | disclosed |