Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 10/20 | 0.67 |
| ▸ | HTR2C | P28335 | 3/20 | 0.67 |
| ▸ | HTR1A | P08908 | 2/20 | 0.67 |
| ▸ | HTR2A | P28223 | 2/20 | 0.67 |
| ▸ | HTR7 | P34969 | 2/20 | 0.67 |
| ▸ | DRD3 | P35462 | 2/20 | 0.67 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | HTR1D | P28221 | 1/20 | 0.56 |
| ▸ | HTR1B | P28222 | 1/20 | 0.56 |
| ▸ | HTR1E | P28566 | 1/20 | 0.56 |
| ▸ | HTR1F | P30939 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.56 |
| ▸ | HTR2B | P41595 | 1/20 | 0.56 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.56 |
| ▸ | RAD52 | P43351 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6975625 | 0.85 | HTR6 (0.78) | HTR6HTR2CHTR1AHTR2AHTR7 | |
| SCHEMBL7089949 | 0.81 | HTR2C (1.00) | HTR6HTR2CHTR1AHTR2AHTR7 | |
| SCHEMBL7201600 | 0.80 | RAD52 (0.73) | HTR6HTR2CHTR1AHTR2AHTR7 | |
| SCHEMBL7086874 | 0.78 | HTR6 (0.59) | HTR6HTR2CHTR1AHTR2AHTR7 | |
| SCHEMBL27567280 | 0.78 | HTR6 (0.58) | HTR6HTR2CHTR1AHTR2AHTR7 | |
| SCHEMBL13757739 | 0.75 | DRD3 (0.60) | HTR6HTR2CHTR1AHTR2AHTR7 | |
| SCHEMBL733291 | 0.74 | HTR6 (0.57) | HTR6HTR2CHTR1AHTR2AHTR7 | |
| SCHEMBL752220 | 0.74 | HTR6 (0.57) | HTR6HTR2CHTR1AHTR2AHTR7 | |
| SCHEMBL1380649 | 0.74 | HTR6 (0.63) | HTR6HTR2CHTR1AHTR2AHTR7 | |
| Hydrochloric Acid SCHEMBL3143290 | 0.74 | DRD3 (0.59) | HTR6HTR2CHTR1AHTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946539-B1 | SULPHONAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 2003-08-13 | — | — | EP | claimed |
| US-6599904-B2 | 5-HT6 receptor antagonists are believed to be of potential use in the treatment of certain CNS disorders; cognitive memory enhancement | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-07-29 | — | — | US | disclosed |