Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 10/20 | 1.00 |
| ▸ | HTR6 | P50406 | 8/20 | 1.00 |
| ▸ | HTR2A | P28223 | 7/20 | 1.00 |
| ▸ | DRD3 | P35462 | 7/20 | 1.00 |
| ▸ | HTR7 | P34969 | 7/20 | 1.00 |
| ▸ | HTR1A | P08908 | 6/20 | 1.00 |
| ▸ | GHSR | Q92847 | 1/20 | 0.67 |
| ▸ | RAD52 | P43351 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | HTR3A | P46098 | 1/20 | 0.55 |
| ▸ | PHGDH | O43175 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | PKLR | P30613 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27496150 | 0.83 | HTR1A (0.71) | HTR2CHTR6HTR2ADRD3HTR7 | |
| SCHEMBL27513811 | 0.82 | HTR6 (0.69) | HTR2CHTR6HTR2ADRD3HTR7 | |
| SCHEMBL27513105 | 0.81 | HTR6 (0.68) | HTR2CHTR6HTR2ADRD3HTR7 | |
| SCHEMBL4800759 | 0.81 | GHSR (1.00) | HTR2CHTR6HTR2ADRD3HTR7 | |
| SCHEMBL4800765 | 0.81 | GHSR (1.00) | HTR2CHTR6HTR2ADRD3HTR7 | |
| SCHEMBL7084057 | 0.81 | HTR6 (0.67) | HTR2CHTR6HTR2ADRD3HTR7 | |
| SCHEMBL7201600 | 0.81 | RAD52 (0.73) | HTR2CHTR6HTR2ADRD3HTR7 | |
| SCHEMBL6975625 | 0.79 | HTR6 (0.78) | HTR2CHTR6HTR2ADRD3HTR7 | |
| SCHEMBL18230177 | 0.78 | HTR7 (0.63) | HTR2CHTR6HTR2ADRD3HTR7 | |
| SCHEMBL13757739 | 0.75 | DRD3 (0.60) | HTR2CHTR6HTR2ADRD3HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946539-B1 | SULPHONAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 2003-08-13 | — | — | EP | claimed |
| US-6599904-B2 | 5-HT6 receptor antagonists are believed to be of potential use in the treatment of certain CNS disorders; cognitive memory enhancement | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-07-29 | — | — | US | disclosed |