Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 2/20 | 0.73 |
| ▸ | HTR6 | P50406 | 11/20 | 0.67 |
| ▸ | HTR2C | P28335 | 9/20 | 0.67 |
| ▸ | HTR2A | P28223 | 7/20 | 0.67 |
| ▸ | DRD3 | P35462 | 7/20 | 0.67 |
| ▸ | HTR1A | P08908 | 6/20 | 0.67 |
| ▸ | HTR7 | P34969 | 5/20 | 0.67 |
| ▸ | HTR3A | P46098 | 1/20 | 0.54 |
| ▸ | GHSR | Q92847 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7089949 | 0.81 | HTR2C (1.00) | RAD52HTR6HTR2CHTR2ADRD3 | |
| SCHEMBL7084057 | 0.80 | HTR6 (0.67) | RAD52HTR6HTR2CHTR2ADRD3 | |
| SCHEMBL6002185 | 0.73 | HTR3A (1.00) | RAD52HTR6HTR2CHTR2ADRD3 | |
| SCHEMBL3613608 | 0.72 | MAPT (0.65) | RAD52HTR6ALDH1A1MAPTKMT2A | |
| SCHEMBL3618341 | 0.71 | RAD52 (0.64) | RAD52HTR6HTR2CHTR2ADRD3 | |
| SCHEMBL3619818 | 0.71 | HTR6 (0.58) | RAD52HTR6HTR2CHTR2ADRD3 | |
| SCHEMBL3622711 | 0.71 | RAD52 (0.55) | RAD52HTR6HTR2CHTR2ADRD3 | |
| Hydrochloric Acid SCHEMBL3619845 | 0.70 | RAD52 (0.65) | RAD52HTR6HTR2CHTR2ADRD3 | |
| Hydrochloric Acid SCHEMBL3611361 | 0.70 | RAD52 (0.56) | RAD52HTR6HTR2CHTR2ADRD3 | |
| SCHEMBL3625538 | 0.70 | RAD52 (0.54) | RAD52HTR6HTR2CHTR2ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6599904-B2 | 5-HT6 receptor antagonists are believed to be of potential use in the treatment of certain CNS disorders; cognitive memory enhancement | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-07-29 | — | — | US | disclosed |