Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 8/20 | 0.59 |
| ▸ | HTR2C | P28335 | 3/20 | 0.59 |
| ▸ | HTR1A | P08908 | 2/20 | 0.59 |
| ▸ | HTR2A | P28223 | 2/20 | 0.59 |
| ▸ | HTR7 | P34969 | 2/20 | 0.59 |
| ▸ | DRD3 | P35462 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | RAD52 | P43351 | 1/20 | 0.51 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.44 |
| ▸ | PKLR | P30613 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6979282 | 0.85 | HTR6 (0.60) | HTR6HTR2CHTR1AHTR2AHTR7 | |
| SCHEMBL6981615 | 0.84 | HTR6 (0.54) | HTR6HTR2CHTR1AHTR2AHTR7 | |
| SCHEMBL7085849 | 0.83 | HTR6 (0.56) | HTR6HTR2CHTR1AHTR2AHTR7 | |
| SCHEMBL6974064 | 0.83 | HTR6 (0.55) | HTR6HTR2CHTR1AHTR2AHTR7 | |
| SCHEMBL6975641 | 0.81 | HTR6 (0.62) | HTR6HTR2CHTR1AHTR2AHTR7 | |
| SCHEMBL6980473 | 0.80 | HTR6 (0.58) | HTR6ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL7084057 | 0.78 | HTR6 (0.67) | HTR6HTR2CHTR1AHTR2AHTR7 | |
| SCHEMBL6975625 | 0.76 | HTR6 (0.78) | HTR6HTR2CHTR1AHTR2AHTR7 | |
| SCHEMBL6980962 | 0.76 | HTR6 (0.64) | HTR6HTR2CDRD3ALDH1A1MAPT | |
| SCHEMBL6972659 | 0.74 | HTR6 (0.53) | HTR6HTR2CDRD3GHSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946539-B1 | SULPHONAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 2003-08-13 | — | — | EP | claimed |
| US-6599904-B2 | 5-HT6 receptor antagonists are believed to be of potential use in the treatment of certain CNS disorders; cognitive memory enhancement | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-07-29 | — | — | US | disclosed |