Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.33 |
| ▸ | XIAP | P98170 | 1/20 | 0.32 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6972647 | 0.95 | ADRA1D (0.34) | ADRA1DPLA2G2AHSP90AA1HSP90B1XIAP | |
| SCHEMBL6965073 | 0.93 | MAPT (0.35) | ADRA1DPLA2G2AKMT2AF10TP53 | |
| SCHEMBL7081480 | 0.93 | ADRA1D (0.34) | ADRA1DPLA2G2AHSP90AA1HSP90B1XIAP | |
| SCHEMBL6970557 | 0.92 | MEN1 (0.34) | ADRA1DHSP90AA1HSP90B1MEN1KMT2A | |
| SCHEMBL6966022 | 0.91 | ADRA1D (0.36) | ADRA1DPLA2G2AHSP90AA1HSP90B1XIAP | |
| SCHEMBL6976014 | 0.91 | PLA2G2A (0.35) | PLA2G2AKMT2AS1PR3KDM4EALDH1A1 | |
| SCHEMBL6966257 | 0.90 | TLR7 (0.35) | PLA2G2ATP53KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6972492 | 0.90 | S1PR3 (0.38) | PLA2G2AS1PR3KDM4EALDH1A1 | |
| SCHEMBL6961282 | 0.89 | SMN1; SMN2 (0.35) | ADRA1DPLA2G2AKMT2AF10TP53 | |
| SCHEMBL7078426 | 0.87 | S1PR3 (0.38) | PLA2G2AKMT2AS1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |