Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.58 |
| ▸ | AHR | P35869 | 2/20 | 0.52 |
| ▸ | F7 | P08709 | 1/20 | 0.52 |
| ▸ | LTA4H | P09960 | 1/20 | 0.52 |
| ▸ | F3 | P13726 | 1/20 | 0.52 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.52 |
| ▸ | GUSB | P08236 | 3/20 | 0.50 |
| ▸ | IKBKB | O14920 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7091089 | 0.86 | AHR (0.52) | NPC1TRPA1AHRIKBKBJAK2 | |
| SCHEMBL22178786 | 0.82 | NPC1 (0.76) | NPC1TRPA1AHRF7LTA4H | |
| SCHEMBL16918805 | 0.81 | NPC1 (0.62) | NPC1TRPA1AHRF7LTA4H | |
| SCHEMBL31504070 | 0.79 | NPC1 (0.61) | NPC1TRPA1AHRGUSBJAK3 | |
| SCHEMBL22178774 | 0.79 | NPC1 (0.61) | NPC1TRPA1AHRGUSBJAK3 | |
| SCHEMBL27561697 | 0.79 | NPC1 (0.61) | NPC1TRPA1AHRF7LTA4H | |
| SCHEMBL398355 | 0.79 | NPC1 (0.61) | NPC1TRPA1AHRF7LTA4H | |
| SCHEMBL27500073 | 0.79 | GUSB (0.68) | NPC1GUSBMAP3K11ALOX5APFEN1 | |
| SCHEMBL7089602 | 0.78 | NPC1 (0.59) | NPC1TRPA1AHRGUSBMAP3K11 | |
| Hydrochloric Acid SCHEMBL27534537 | 0.77 | NPC1 (0.57) | NPC1TRPA1AHRGUSBMAP3K11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030203959-A1 | Novel modulators of potassium channels | 4SC AG (DE) | 2003-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030203959-A1 | Novel modulators of potassium channels | HCN3, KCNN3, KCNN1 | NPC1 487/4885TRPA1 96/4885AHR 379/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.