Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | GUSB | P08236 | 3/20 | 0.49 |
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.47 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.47 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.47 |
| ▸ | ITGAL | P20701 | 1/20 | 0.47 |
| ▸ | CA4 | P22748 | 1/20 | 0.47 |
| ▸ | CA6 | P23280 | 1/20 | 0.47 |
| ▸ | AHR | P35869 | 1/20 | 0.47 |
| ▸ | ADK | P55263 | 1/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27534537 | 0.98 | NPC1 (0.57) | NPC1GUSBMAP3K11CASP3SENP7 | |
| SCHEMBL12223921 | 0.89 | NPC1 (0.57) | NPC1GUSBMAP3K11CASP3SENP7 | |
| SCHEMBL8995170 | 0.87 | PIK3CD (0.51) | NPC1CA1CA2TRPA1ITGB2 | |
| SCHEMBL7088454 | 0.85 | PIK3CD (0.62) | NPC1GUSBMAP3K11CASP3SENP7 | |
| SCHEMBL15810995 | 0.81 | NPC1 (0.53) | NPC1GUSBMAP3K11CASP3SENP7 | |
| SCHEMBL22178786 | 0.81 | NPC1 (0.76) | NPC1GUSBMAP3K11CASP3SENP7 | |
| SCHEMBL16918805 | 0.79 | NPC1 (0.62) | NPC1GUSBMAP3K11CASP3SENP7 | |
| SCHEMBL12224208 | 0.79 | NPC1 (0.50) | NPC1GUSBMAP3K11CASP3SENP7 | |
| SCHEMBL940968 | 0.79 | MAP3K11 (0.58) | NPC1MAP3K11CASP3SENP7SENP6 | |
| SCHEMBL22649086 | 0.78 | ALOX5 (0.57) | NPC1GUSBMAP3K11CASP3SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1092765-A | New tryptamine analogues and preparation method thereof and purposes | SMITHKLINE BEECHAM PLC (GB) | 1994-09-28 | — | — | CN | claimed |
| US-20030203959-A1 | Novel modulators of potassium channels | 4SC AG (DE) | 2003-10-30 | — | — | US | disclosed |
| EP-0674620-A1 | TRYPTAMINE ANALOGUES AS 5-HT 1?-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-10-04 | — | — | EP | disclosed |
| CN-1092765-A | New tryptamine analogues and preparation method thereof and purposes | SMITHKLINE BEECHAM PLC (GB) | 1994-09-28 | — | — | CN | disclosed |
| WO-1994014771-A1 | TRYPTAMINE ANALOGUES AS 5-HT1-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030203959-A1 | Novel modulators of potassium channels | HCN3, KCNN3, KCNN1 | NPC1 487/4885GUSB 3930/4885MAP3K11 2694/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.