Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 10/20 | 0.46 |
| ▸ | THRB | P10828 | 10/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | HTR2B | P41595 | 2/20 | 0.43 |
| ▸ | HTR1D | P28221 | 3/20 | 0.40 |
| ▸ | HTR1B | P28222 | 3/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7088599 | 0.84 | THRA (0.45) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL7086230 | 0.82 | THRA (0.60) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL6512292 | 0.82 | THRA (0.59) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL6512367 | 0.81 | THRB (0.63) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL7091262 | 0.80 | THRA (0.61) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL7082352 | 0.78 | THRA (0.69) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL6515707 | 0.77 | THRB (0.60) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL29844872 | 0.71 | ROCK1 (0.48) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL12180277 | 0.71 | HTR2B (0.70) | HTR2AHTR2CHTR2BHTR1DHTR1B | |
| SCHEMBL7085352 | 0.71 | THRA (0.53) | THRATHRBHTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268422-A1 | INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES | Bayer Aktiengesellschaft (DE) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070687-A1 | INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES | BAYER AKTIENGESELLSCHAFT (DE) | 2001-09-27 | — | — | WO | disclosed |