Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7086925 | 0.65 | ALDH1A1 (0.43) | MAPTPOLBNPC1RAB9ANPSR1 | |
| SCHEMBL7086502 | 0.62 | TP53 (0.40) | MAPTPOLBNPC1RAB9ANPSR1 | |
| SCHEMBL770898 | 0.59 | POLB (0.44) | MAPTRXFP1POLBNPC1PKM | |
| SCHEMBL16604858 | 0.58 | KDM4E (0.55) | MAPTPOLBNPC1RAB9ACASP3 | |
| SCHEMBL7388070 | 0.58 | PTGS2 (0.46) | MAPTRXFP1POLBNPC1PKM | |
| SCHEMBL7921236 | 0.57 | CYP2A6 (0.47) | MAPTRXFP1POLBNPC1PKM | |
| SCHEMBL16252211 | 0.57 | POLB (0.45) | MAPTRXFP1POLBNPC1PKM | |
| SCHEMBL28002826 | 0.57 | ALDH1A1 (0.42) | MAPTRXFP1POLBNPC1RAB9A | |
| SCHEMBL16604861 | 0.56 | MAPT (0.51) | MAPTRXFP1POLBNPC1PKM | |
| SCHEMBL14833010 | 0.56 | NPC1 (0.40) | MAPTRXFP1POLBNPC1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326613-A1 | USE OF SUBSTITUTED IMIDAZO 1,2-A]PYRIDINE-, IMIDAZO 1,2-A]PYRIMIDINE AND IMIDAZO 1,2-A]PYRAZINE-3-YL-AMINE DERIVATIVES FOR PRODUCING NOS-INHIBITING MEDICAMENTS | Grünenthal GmbH (DE) | 2003-07-16 | — | — | EP | claimed |
| WO-2002030428-A1 | USE OF SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE-, IMIDAZO[1,2-A]PYRIMIDINE AND IMIDAZO[1,2-A]PYRAZINE-3-YL-AMINE DERIVATIVES FOR PRODUCING NOS-INHIBITING MEDICAMENTS | Grünenthal GmbH (DE) | 2002-04-18 | — | — | WO | claimed |