Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 8/20 | 0.44 |
| ▸ | THRB | P10828 | 8/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | HTR1B | P28222 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7085214 | 0.88 | THRA (0.44) | THRATHRBSLC6A4HTR6HTR1A | |
| SCHEMBL7089914 | 0.86 | THRA (0.47) | THRATHRBHTR1AHTR1BMTNR1A | |
| SCHEMBL6519382 | 0.85 | THRA (0.61) | THRATHRBMTNR1A | |
| SCHEMBL6520487 | 0.84 | THRA (0.49) | THRATHRBHTR1AHTR1BMTNR1A | |
| SCHEMBL6985820 | 0.84 | THRA (0.46) | THRATHRBSLC6A4HTR1AHTR1B | |
| SCHEMBL7093058 | 0.84 | THRA (0.41) | THRATHRBSLC6A4HTR6HTR1A | |
| SCHEMBL7087918 | 0.83 | HTR1A (0.42) | THRATHRBSLC6A4HTR6HTR1A | |
| SCHEMBL7138821 | 0.82 | HTR1D (0.42) | THRATHRBHTR6HTR1BMTNR1A | |
| SCHEMBL6520683 | 0.82 | THRA (0.60) | THRATHRBHTR6HTR1AHTR1B | |
| SCHEMBL6518435 | 0.82 | THRA (0.60) | THRATHRBHTR6HTR1AHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347959-A1 | INDOLE DERIVATIVES AS LIGANDS OF THYROID RECEPTORS | Bayer Aktiengesellschaft (DE) | 2003-10-01 | — | — | EP | disclosed |
| WO-2002051805-A1 | INDOLE DERIVATIVES AS LIGANDS OF THYROID RECEPTORS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-07-04 | — | — | WO | disclosed |