Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 7/20 | 0.49 |
| ▸ | THRB | P10828 | 7/20 | 0.49 |
| ▸ | HTR2C | P28335 | 3/20 | 0.46 |
| ▸ | HTR2B | P41595 | 3/20 | 0.46 |
| ▸ | HTR1A | P08908 | 3/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | HTR1B | P28222 | 3/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7088760 | 0.87 | THRA (0.52) | THRATHRBHTR2CHTR2BHTR1A | |
| SCHEMBL7087898 | 0.83 | HTR2C (0.49) | THRATHRBHTR2CHTR2BHTR1A | |
| SCHEMBL6985830 | 0.83 | HTR2A (0.49) | THRATHRBHTR2CHTR2BHTR1A | |
| SCHEMBL7084815 | 0.82 | THRA (0.50) | THRATHRBHTR2CHTR2BHTR1A | |
| SCHEMBL6510913 | 0.81 | THRA (0.75) | THRATHRBHTR2CHTR2BHTR1A | |
| SCHEMBL7088995 | 0.81 | THRA (0.56) | THRATHRBHTR2CHTR2BHTR2A | |
| SCHEMBL7088864 | 0.81 | THRA (0.47) | THRATHRBHTR1AHTR1BGPR84 | |
| SCHEMBL6512432 | 0.81 | THRA (0.60) | THRATHRBHTR2CHTR2BHTR1A | |
| SCHEMBL7087920 | 0.81 | HTR1A (0.44) | THRATHRBHTR1AHTR1BSLC6A4 | |
| SCHEMBL6981325 | 0.80 | THRA (0.48) | THRATHRBHTR2CHTR2BHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268422-A1 | INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES | Bayer Aktiengesellschaft (DE) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070687-A1 | INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES | BAYER AKTIENGESELLSCHAFT (DE) | 2001-09-27 | — | — | WO | disclosed |