Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.49 |
| ▸ | HTR2A | P28223 | 5/20 | 0.49 |
| ▸ | HTR2B | P41595 | 4/20 | 0.49 |
| ▸ | HTR1A | P08908 | 4/20 | 0.49 |
| ▸ | HTR1B | P28222 | 4/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.43 |
| ▸ | THRA | P10827 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HTR6 | P50406 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6985830 | 0.86 | HTR2A (0.49) | HTR2CHTR2AHTR2BHTR1AHTR1B | |
| SCHEMBL6989252 | 0.86 | HTR2B (0.49) | HTR2CHTR2AHTR2BHTR1AHTR1B | |
| SCHEMBL7085334 | 0.83 | THRA (0.49) | HTR2CHTR2AHTR2BHTR1AHTR1B | |
| SCHEMBL7090659 | 0.81 | HTR1A (0.52) | HTR2AHTR1AHTR1BCYP1A2CYP2D6 | |
| SCHEMBL6987463 | 0.81 | HTR1A (0.53) | HTR2AHTR1AHTR1BCYP1A2CYP2D6 | |
| SCHEMBL6510961 | 0.80 | THRB (0.54) | HTR2CHTR2AHTR2BHTR1ATHRA | |
| SCHEMBL6984598 | 0.80 | HTR2C (0.53) | HTR2CHTR2AHTR2BHTR1AHTR1B | |
| SCHEMBL6515823 | 0.79 | KDM4E (0.48) | HTR2CHTR2AHTR2BHTR1AHTR1B | |
| SCHEMBL25082193 | 0.76 | HTR2A (0.78) | HTR2CHTR2AHTR2BHTR1AHTR1B | |
| SCHEMBL7088760 | 0.76 | THRA (0.52) | HTR2CHTR2AHTR2BHTR1AHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347959-A1 | INDOLE DERIVATIVES AS LIGANDS OF THYROID RECEPTORS | Bayer Aktiengesellschaft (DE) | 2003-10-01 | — | — | EP | disclosed |
| WO-2002051805-A1 | INDOLE DERIVATIVES AS LIGANDS OF THYROID RECEPTORS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-07-04 | — | — | WO | disclosed |