Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 9/20 | 0.48 |
| ▸ | THRB | P10828 | 9/20 | 0.48 |
| ▸ | HTR2A | P28223 | 3/20 | 0.42 |
| ▸ | HTR2C | P28335 | 3/20 | 0.42 |
| ▸ | HTR2B | P41595 | 3/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | HTR1B | P28222 | 2/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6520117 | 0.85 | THRB (0.67) | THRATHRB | |
| SCHEMBL6985253 | 0.84 | HTR1A (0.45) | THRATHRBHTR2AHTR1ACYP1A2 | |
| SCHEMBL6516349 | 0.84 | THRA (0.54) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL6988067 | 0.83 | THRA (0.54) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL7088760 | 0.82 | THRA (0.52) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL7087918 | 0.82 | HTR1A (0.42) | THRATHRBHTR1AHTR1BHTR1D | |
| SCHEMBL7085334 | 0.80 | THRA (0.49) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL6510913 | 0.79 | THRA (0.75) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL6989252 | 0.79 | HTR2B (0.49) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL6512432 | 0.78 | THRA (0.60) | THRATHRBHTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347959-A1 | INDOLE DERIVATIVES AS LIGANDS OF THYROID RECEPTORS | Bayer Aktiengesellschaft (DE) | 2003-10-01 | — | — | EP | disclosed |
| WO-2002051805-A1 | INDOLE DERIVATIVES AS LIGANDS OF THYROID RECEPTORS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-07-04 | — | — | WO | disclosed |