Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Benzofuran. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 6/20 | 0.41 |
| ▸ | WNT3A | P56704 | 6/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 7/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA3 | P07451 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.35 |
| ▸ | EPM2A | O95278 | 1/20 | 0.35 |
| ▸ | PTPRC | P08575 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzofuran SCHEMBL5860505 | 0.89 | MAOA (0.39) | CTNNB1WNT3AMAOAMAOBFTO | |
| Benzofuran SCHEMBL28153539 | 0.89 | MAOA (0.41) | CTNNB1WNT3AMAOAMAOBFTO | |
| Benzofuran SCHEMBL9296271 | 0.87 | LOXL2 (0.39) | CTNNB1WNT3AMAOAMAOBFTO | |
| Benzofuran SCHEMBL3160534 | 0.86 | — | — | |
| Benzofuran SCHEMBL29415475 | 0.86 | — | — | |
| Benzofuran SCHEMBL5564 | 0.86 | — | — | |
| Benzofuran SCHEMBL5834531 | 0.86 | MAOA (0.46) | CTNNB1WNT3AMAOAMAOBFTO | |
| Benzofuran SCHEMBL29393518 | 0.86 | — | — | |
| Benzofuran SCHEMBL29006510 | 0.85 | MEN1 (0.39) | CTNNB1WNT3AMAOAMAOBFTO | |
| Benzofuran SCHEMBL28812676 | 0.84 | CTNNB1 (0.47) | CTNNB1WNT3AMAOAMAOBFTO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105801594-B | A kind of synthetic method of river radix paeoniae rubrathe alcohol and its analogue | 陕西师范大学 | 2018-01-12 | — | — | CN | claimed |
| CN-105801594-A | Synthetic method of paeonia veitchii lynch alcohol and structural analogue thereof | 陕西师范大学 | 2016-07-27 | — | — | CN | claimed |
| CN-106573904-B | Method for generating beraprost and its derivative | 朗格生物技术公共公益股份有限公司 | 2019-11-08 | — | — | CN | disclosed |
| CN-109054648-A | Serosity combination for chemically mechanical polishing | LTCAM有限公司 | 2018-12-21 | — | — | CN | disclosed |
| CN-109069664-A | anti-CD 74 antibody conjugates, compositions comprising anti-CD 74 antibody conjugates, and methods of use of anti-CD 74 antibody conjugates | 苏特罗生物制药公司 | 2018-12-21 | — | — | CN | disclosed |
| CN-105801594-B | A kind of synthetic method of river radix paeoniae rubrathe alcohol and its analogue | 陕西师范大学 | 2018-01-12 | — | — | CN | disclosed |
| CN-107266345-A | It is used as (miscellaneous) aryl rings propanamine compounds of LSD1 inhibitor | 奥瑞泽恩基因组学股份有限公司 | 2017-10-20 | — | — | CN | disclosed |
| CN-104203914-B | (hetero) arylcyclopropylamine compounds as LSD1 inhibitors | 奥瑞泽恩基因组学股份有限公司 | 2017-07-11 | — | — | CN | disclosed |
| CN-106573904-A | Methods for producing beraprost and its derivatives | 朗格生物技术公共公益股份有限公司 | 2017-04-19 | — | — | CN | disclosed |
| CN-105801594-A | Synthetic method of paeonia veitchii lynch alcohol and structural analogue thereof | 陕西师范大学 | 2016-07-27 | — | — | CN | disclosed |
| CN-1520805-A | Ubiquinone containing composition | 日清药业股份有限公司 | 2004-08-18 | — | — | CN | disclosed |
| US-20030055084-A1 | Pharmaceutical compounds and methods of use thereof | MILLENNIUM PHARMACEUTICAL, INC. | 2003-03-20 | — | — | US | disclosed |
| WO-2003011848-A1 | BENZOHETEROCYCLES AS LIPOXYGENASE INHITIBORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2003-02-13 | — | — | WO | disclosed |
| US-4758676-A | Intermediates for antiatherosclerotic furochromones | THE UPJOHN COMPANY (US) | 1988-07-19 | — | — | US | disclosed |
| US-4623737-A | Synthesis of precursors of anti-atherosclerotic furochromones | THE UPJOHN COMPANY (US) | 1986-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030055084-A1 | Pharmaceutical compounds and methods of use thereof | CYP3A5, DHPS, CYP3A43 | CTNNB1 3360/4885WNT3A 4257/4885MAOA 146/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.