Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 14/20 | 0.56 |
| ▸ | GHSR | Q92847 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | TYMS | P04818 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7086874 | 0.83 | HTR6 (0.59) | HTR6GHSRHTR1AHTR2AHTR2C | |
| SCHEMBL6981615 | 0.79 | HTR6 (0.54) | HTR6HTR1AHTR2AHTR2CHTR7 | |
| SCHEMBL6980473 | 0.79 | HTR6 (0.58) | HTR6ALDH1A1 | |
| SCHEMBL6974064 | 0.78 | HTR6 (0.55) | HTR6HTR1AHTR2AHTR2CHTR7 | |
| SCHEMBL6979282 | 0.78 | HTR6 (0.60) | HTR6HTR1AHTR2AHTR2CHTR7 | |
| SCHEMBL6978521 | 0.77 | HTR6 (0.61) | HTR6HTR1AHTR2AHTR2CHTR7 | |
| SCHEMBL6977914 | 0.77 | HTR6 (0.59) | HTR6ALDH1A1 | |
| SCHEMBL6980564 | 0.77 | GHSR (0.71) | HTR6GHSRHTR1AHTR2AHTR2C | |
| SCHEMBL6975641 | 0.76 | HTR6 (0.62) | HTR6HTR1AHTR2AHTR2CHTR7 | |
| SCHEMBL6980962 | 0.75 | HTR6 (0.64) | HTR6HTR2CDRD3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946539-B1 | SULPHONAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 2003-08-13 | — | — | EP | claimed |
| CN-1246116-A | Sulfonamide derivatives, process for their preparation and their use as medicaments | SMITHKLINE BEECHAM PLC (GB) | 2000-03-01 | — | — | CN | claimed |
| US-6599904-B2 | 5-HT6 receptor antagonists are believed to be of potential use in the treatment of certain CNS disorders; cognitive memory enhancement | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-07-29 | — | — | US | disclosed |