Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 10/20 | 0.48 |
| ▸ | THRB | P10828 | 10/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7088676 | 0.91 | THRA (0.56) | THRATHRBKMT2AMEN1ALDH1A1 | |
| SCHEMBL7174740 | 0.85 | HTR1A (0.46) | KMT2AMEN1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7164253 | 0.84 | HTR1A (0.47) | KMT2AMEN1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7088630 | 0.75 | THRA (0.47) | THRATHRBALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL7130898 | 0.73 | THRA (0.38) | THRATHRBKMT2AMEN1ALDH1A1 | |
| SCHEMBL7089721 | 0.71 | THRA (0.45) | THRATHRBKMT2AMEN1ALDH1A1 | |
| SCHEMBL13381600 | 0.69 | THRA (0.56) | THRATHRBCYP1A2KDM4EHTR1A | |
| SCHEMBL7135882 | 0.69 | THRA (0.43) | THRATHRBHTR1AHTR1B | |
| SCHEMBL6862010 | 0.69 | KDM4E (0.53) | THRATHRBKMT2AMEN1KDM4E | |
| SCHEMBL6515562 | 0.68 | MTNR1A (0.50) | THRATHRBKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268422-A1 | INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES | Bayer Aktiengesellschaft (DE) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070687-A1 | INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES | BAYER AKTIENGESELLSCHAFT (DE) | 2001-09-27 | — | — | WO | disclosed |