Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 5/20 | 0.38 |
| ▸ | THRB | P10828 | 5/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.33 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.33 |
| ▸ | TTK | P33981 | 4/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.32 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7135882 | 0.94 | THRA (0.43) | THRATHRBHSP90AA1HSP90AB1PRKAG1 | |
| SCHEMBL7140230 | 0.80 | THRA (0.53) | THRATHRBTTKMAPK8 | |
| SCHEMBL7088676 | 0.80 | THRA (0.56) | THRATHRBMEN1KMT2AALDH1A1 | |
| SCHEMBL7138299 | 0.78 | THRA (0.38) | THRATHRBPRKAG1PRKAA1PRKAB1 | |
| SCHEMBL7141223 | 0.78 | CNR2 (0.41) | THRATHRBTTKMEN1KMT2A | |
| SCHEMBL7130895 | 0.75 | THRA (0.66) | THRATHRB | |
| SCHEMBL7133145 | 0.74 | THRA (0.60) | THRATHRBTTKMAPK8 | |
| SCHEMBL7085855 | 0.73 | THRA (0.48) | THRATHRBMEN1KMT2AALDH1A1 | |
| SCHEMBL7230331 | 0.72 | THRB (0.51) | THRATHRBTTKMAPK8TSHR | |
| SCHEMBL7138386 | 0.71 | THRA (0.43) | THRATHRBMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1324987-A1 | INDAZOLES WITH THYROID HORMON LIKE ACTIVITY, A PROCESS FOR ITS PREPARATION AND ITS USE IN PHARMACEUTICAL COMPOSITIONS | Bayer Aktiengesellschaft (DE) | 2003-07-09 | — | — | EP | disclosed |
| WO-2002022586-A1 | INDAZOLES HAVING AN ACTION SIMILAR TO THAT OF A THYROID HORMONE, METHOD FOR THE PRODUCTION THEREOF, AND THEIR USE IN MEDICAMENTS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-03-21 | — | — | WO | disclosed |