SCHEMBL7086124

SCHEMBL7086124

Cc1cc(C)cc(Sc2c(C(C)C)nc(CCO)n2Cc2ccccn2)c1

nearest known ligand 0.35

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 10/20 0.35
H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 P62805 9/20 0.35
HRH1 P35367 1/20 0.34
TLR7 Q9NYK1 2/20 0.33
PHGDH O43175 1/20 0.33
GABRA1 P14867 1/20 0.33
GABRA5 P31644 1/20 0.33
KMT2A Q03164 1/20 0.32
ALOX5AP P20292 1/20 0.32
GRIN1 Q05586 1/20 0.32
GRIN2B Q13224 1/20 0.32
PTGDR2 Q9Y5Y4 1/20 0.32
TLR9 Q9NR96 1/20 0.32
TLR8 Q9NR97 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6974738 0.94 TLR7 (0.36) BRD4H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16HRH1TLR7PHGDH
SCHEMBL7081548 0.92 BRD4 (0.36) BRD4H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16HRH1TLR7PHGDH
SCHEMBL7084157 0.90 TLR7 (0.37) HRH1TLR7ALOX5APPTGDR2
SCHEMBL7082531 0.89 HRH1 (0.34) HRH1TLR7KMT2AALOX5APGRIN1
SCHEMBL6967358 0.89 S1PR3 (0.35) HRH1TLR7ALOX5APGRIN1GRIN2B
SCHEMBL7082502 0.85 BRD4 (0.38) BRD4TLR7KMT2A
SCHEMBL7082472 0.85 ALDH1A1 (0.37) HRH1TLR7KMT2AGRIN1GRIN2B
SCHEMBL6973313 0.85 GRIN1 (0.38) HRH1TLR7KMT2AGRIN1GRIN2B
SCHEMBL6976014 0.85 PLA2G2A (0.35) BRD4H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16KMT2APTGDR2
SCHEMBL6974739 0.84 PLA2G2A (0.35) BRD4H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16TLR7KMT2APTGDR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786455-B1 IMIDAZOLE DERIVATIVE SHIONOGI & CO (JP) 2003-12-03 EP disclosed
US-6147097-A METHOD FOR TREATING AIDS SHIONOGI & CO., LTD. (JP) 2000-11-14 US disclosed
US-5910506-A IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC SHIONOGI & CO., LTD. (JP) 1999-06-08 US disclosed
EP-0786455-A1 IMIDAZOLE DERIVATIVE SHIONOGI & CO., LTD. (JP) 1997-07-30 EP disclosed