SCHEMBL7086206

SCHEMBL7086206

Nc1ccnn1-c1ccc(C(F)(F)F)cc1Cl

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.42
KDM4E B2RXH2 2/20 0.42
LMNA P02545 1/20 0.42
PKM P14618 1/20 0.41
GABRA2 P47869 4/20 0.39
GABRB2 P47870 4/20 0.39
GABRP O00591 3/20 0.39
GABRD O14764 3/20 0.39
GABRA1 P14867 3/20 0.39
GABRB1 P18505 3/20 0.39
GABRG2 P18507 3/20 0.39
GABRB3 P28472 3/20 0.39
GABRA5 P31644 3/20 0.39
GABRA3 P34903 3/20 0.39
GABRA4 P48169 3/20 0.39
GABRE P78334 3/20 0.39
GABRA6 Q16445 3/20 0.39
GABRG1 Q8N1C3 3/20 0.39
GABRG3 Q99928 3/20 0.39
GABRQ Q9UN88 3/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10555780 0.82 ALDH1A1 (0.42) ALDH1A1KDM4ELMNAPKMGABRB3
SCHEMBL9458856 0.81 GABRB3 (0.54) GABRA2GABRB2GABRPGABRDGABRA1
SCHEMBL5178662 0.79 LMNA (0.43) ALDH1A1LMNAPKMPOLBMARS1
SCHEMBL10400984 0.77 GABRB3 (0.46) GABRA2GABRB2GABRPGABRDGABRA1
SCHEMBL4539912 0.77 KMT2A (0.50) ALDH1A1KDM4ELMNAPOLBSMN1; SMN2
SCHEMBL7086689 0.75 GABRB3 (0.45) GABRA2GABRB2GABRPGABRDGABRA1
SCHEMBL10772405 0.75 ALDH1A1 (0.40) ALDH1A1KDM4ELMNAPKMGABRA2
SCHEMBL28463471 0.75 GABRA2 (0.44) ALDH1A1KDM4ELMNAPKMGABRA2
SCHEMBL18328165 0.74 DDR1 (0.38) ALDH1A1KDM4ELMNAPKM
SCHEMBL28878347 0.74 POLB (0.58) POLBMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2003064384-A2 ENVIRONMENT FRIENDLY REAGENTS AND PROCESS FOR TRIFLUOROMETHYLSULFINYLATION OF ORGANIC COMPOUNDS VIRBAC S.A. (FR) 2003-08-07 WO claimed
EP-1331222-A1 Environment friendly reagents and process for halogenoalkylsulfinylation of organic compounds VIRBAC S.A. (FR) 2003-07-30 EP claimed
WO-2003064384-A2 ENVIRONMENT FRIENDLY REAGENTS AND PROCESS FOR TRIFLUOROMETHYLSULFINYLATION OF ORGANIC COMPOUNDS VIRBAC S.A. (FR) 2003-08-07 WO disclosed
EP-1331222-A1 Environment friendly reagents and process for halogenoalkylsulfinylation of organic compounds VIRBAC S.A. (FR) 2003-07-30 EP disclosed