Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 10/20 | 0.57 |
| ▸ | PDE4A | P27815 | 9/20 | 0.57 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | PDE5A | O76074 | 1/20 | 0.47 |
| ▸ | PDE1A | P54750 | 1/20 | 0.47 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.47 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7325326 | 0.87 | ALDH1A1 (0.68) | ALDH1A1TSHRMAPK10EPHX2POLB | |
| SCHEMBL7088472 | 0.80 | PDE4B (0.65) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| SCHEMBL7417873 | 0.78 | PDE4B (0.62) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| SCHEMBL3437003 | 0.77 | ALDH1A1 (0.66) | ALDH1A1TSHRMAPK10EPHX2POLB | |
| SCHEMBL13317191 | 0.76 | RECQL (0.61) | PDE4BPDE4APDE4CPDE4DRECQL | |
| SCHEMBL7026447 | 0.76 | PDE4B (0.58) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| SCHEMBL3170776 | 0.75 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4DRECQL | |
| SCHEMBL8579115 | 0.75 | NPC1 (0.55) | ALDH1A1POLB | |
| SCHEMBL7091205 | 0.74 | PDE4B (0.57) | PDE4BPDE4APDE4CPDE4DRECQL | |
| SCHEMBL7477238 | 0.74 | RECQL (0.62) | PDE4BPDE4APDE4CPDE4DRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0814809-B1 | ARYL THIOXANTHINES | EURO CELTIQUE SA (LU) | 2003-08-13 | — | — | EP | disclosed |
| US-6440979-B1 | Aryl isoguanines | EURO-CELTIQUE, S.A. (LU) | 2002-08-27 | — | — | US | disclosed |
| US-6090816-A | ANTIASTHMA AGENTS | EURO-CELTIQUE S.A. (LU) | 2000-07-18 | — | — | US | disclosed |
| US-6066641-A | PHOSPHODIESTERASES AS MOLECULAR TARGETS FOR ANTI-ASTHMATIC AGENTS | EURO-CELTIQUE S.A. (LU) | 2000-05-23 | — | — | US | disclosed |
| EP-0814809-A4 | ARYL THIOXANTHINES | EURO CELTIQUE SA (LU) | 1998-04-01 | — | — | EP | disclosed |
| EP-0814809-A1 | ARYL THIOXANTHINES | Euroceltique S.A. (LU) | 1998-01-07 | — | — | EP | disclosed |
| WO-1996018399-A1 | ARYL THIOXANTHINES | EURO-CELTIQUE, S.A. (LU) | 1996-06-20 | — | — | WO | disclosed |