Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RHEB | Q15382 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.31 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6973420 | 0.94 | SMN1; SMN2 (0.35) | KMT2APGRADORA3PTGS1SLC6A2 | |
| SCHEMBL7080029 | 0.91 | PTPRA (0.34) | PGRADORA3PTGS1SLC6A2TAS1R3 | |
| SCHEMBL8113590 | 0.90 | MAOB (0.32) | PGRADORA3PTGS1SLC6A2HDAC6 | |
| SCHEMBL7164320 | 0.89 | RHEB (0.31) | RHEB | |
| SCHEMBL7078977 | 0.89 | RHEB (0.34) | MEN1KMT2ARHEBPGRADORA3 | |
| SCHEMBL7078551 | 0.87 | SLC6A9 (0.33) | KMT2APGRADORA3PTGS1SLC6A2 | |
| SCHEMBL6973846 | 0.86 | — | — | |
| SCHEMBL6969216 | 0.85 | MEN1 (0.34) | MEN1KMT2ANPC1 | |
| SCHEMBL6975428 | 0.84 | CYP1A2 (0.35) | MEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL6966214 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |