SCHEMBL7088686

SCHEMBL7088686

CCCCCCc1c[nH]c2ccc(Oc3c(Br)cc(N)cc3Br)cc12

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR1B P28222 14/20 0.57
HTR1A P08908 14/20 0.57
HTR1D P28221 11/20 0.57
MAPT P10636 3/20 0.57
MAPK1 P28482 2/20 0.57
TDP1 Q9NUW8 2/20 0.57
CYP1A2 P05177 2/20 0.57
HTR2A P28223 2/20 0.57
KDM4E B2RXH2 1/20 0.57
TP53 P04637 1/20 0.57
CYP3A4 P08684 1/20 0.57
CYP2D6 P10635 1/20 0.57
CYP2C9 P11712 1/20 0.57
CYP2C19 P33261 1/20 0.57
NPSR1 Q6W5P4 2/20 0.56
MEN1 O00255 1/20 0.56
KMT2A Q03164 1/20 0.56
TRPM8 Q7Z2W7 2/20 0.46
TSHR P16473 1/20 0.46
NFKB1 P19838 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7084332 0.99 HTR1B (0.56) HTR1BHTR1AHTR1DMAPTMAPK1
SCHEMBL7090377 0.95 HTR1A (0.54) HTR1BHTR1AHTR1DMAPTMAPK1
SCHEMBL7090401 0.91 HTR1A (0.52) HTR1BHTR1AHTR1DMAPTMAPK1
SCHEMBL6987463 0.88 HTR1A (0.53) HTR1BHTR1AHTR1DMAPTMAPK1
SCHEMBL7090659 0.86 HTR1A (0.52) HTR1BHTR1AHTR1DMAPTMAPK1
SCHEMBL7088534 0.85 HTR1B (0.48) HTR1BHTR1AHTR1DMAPTMAPK1
SCHEMBL6515801 0.84 THRA (0.50) HTR1BHTR1AHTR1DMAPTMAPK1
SCHEMBL7082793 0.84 LTA4H (0.48) HTR1BHTR1AHTR1DMAPTMAPK1
SCHEMBL6515161 0.84 HTR1A (0.49) HTR1BHTR1AHTR1DMAPTMAPK1
SCHEMBL7087277 0.84 HTR1B (0.52) HTR1BHTR1AHTR1DMAPTMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1268422-A1 INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES Bayer Aktiengesellschaft (DE) 2003-01-02 EP disclosed
WO-2001070687-A1 INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES BAYER AKTIENGESELLSCHAFT (DE) 2001-09-27 WO disclosed