SCHEMBL7089068

SCHEMBL7089068

COC(=O)N(c1cc(NS(C)(=O)=O)ccc1C(=O)Nc1ccc2ccn(C(=O)OC(C)(C)C)c2c1)C1CCN(c2ccncc2)CC1

nearest known ligand 0.36

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 4/20 0.36
F10 P00742 8/20 0.34
KIF18A Q8NI77 3/20 0.33
LMNA P02545 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
MAPK14 Q16539 1/20 0.32
CACNA2D1 P54289 1/20 0.32
TGFBR1 P36897 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6172499 0.90 F10 (0.35) GPR119F10SMN1; SMN2MAPK14
SCHEMBL6170084 0.89 GPR119 (0.36) GPR119F10KIF18AMAPK14
SCHEMBL6169102 0.87 F10 (0.39) F10LMNA
SCHEMBL6170090 0.85 F10 (0.41) F10
SCHEMBL6168757 0.84 F10 (0.43) F10
SCHEMBL6168830 0.82 F10 (0.36) GPR119F10KIF18AMAPK14TGFBR1
SCHEMBL6171243 0.79 GPR119 (0.36) GPR119F10SMN1; SMN2MAPK14
SCHEMBL6171172 0.77 F10 (0.38) GPR119F10LMNA
SCHEMBL6169725 0.76 F10 (0.39) F10
SCHEMBL7082624 0.76 F10 (0.45) F10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20030078431-A1 Antithrombotic agents BEIGHT DOUGLAS WADE (US) 2003-04-24 US disclosed
US-6500851-B2 ANTICOAGULANT IN MAMMLS ELI LILLY AND COMPANY 2002-12-31 US disclosed
US-20020173518-A1 Antithrombotic agents BEIGHT DOUGLAS WADE (US) 2002-11-21 US disclosed
US-6372759-B1 BLOOD COAGULATION FACTOR XA FOR MAMMALS ELI LILLY AND COMPANY 2002-04-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020173518-A1 Antithrombotic agents SERPINC1, TFPI, F11 GPR119 1388/4885F10 15/4885KIF18A 4553/4885
US-20030078431-A1 Antithrombotic agents SERPINC1, TFPI, F11 GPR119 1388/4885F10 15/4885KIF18A 4553/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.