Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1550030 | 0.82 | PGR (0.36) | PGRADRA2AADRA2BHTR2AHRH1 | |
| SCHEMBL15559838 | 0.67 | TSHR (0.39) | ALDH1A1 | |
| SCHEMBL24035819 | 0.64 | HCAR3 (0.35) | ALDH1A1 | |
| SCHEMBL29132918 | 0.64 | HCAR3 (0.37) | ALDH1A1 | |
| SCHEMBL18696360 | 0.64 | TSHR (0.39) | ALDH1A1 | |
| SCHEMBL1080178 | 0.62 | KDM4E (0.42) | ALDH1A1 | |
| SCHEMBL22748596 | 0.62 | ALDH1A1 (0.41) | ALDH1A1 | |
| SCHEMBL29132876 | 0.62 | HCAR3 (0.38) | ALDH1A1 | |
| SCHEMBL24853072 | 0.62 | HCAR3 (0.46) | ALDH1A1 | |
| SCHEMBL969727 | 0.60 | AKR1B1 (0.46) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370554-A1 | 3-(4-AMIDOPYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS PROTEIN KINASE INHIBITORS | PHARMACIA & UPJOHN COMPANY (US) | 2003-12-17 | — | — | EP | claimed |
| WO-2002066463-A1 | 3-(4-AMIDOPYRROL-2-YLMETHLIDENE)-2-INDOLINONE DERIVATIVES AS PROTEIN KINASE INHIBITORS | PHARMACIA & UPJOHN COMPANY (US) | 2002-08-29 | — | — | WO | claimed |