Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.36 |
| ▸ | CDK2 | P24941 | 3/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | CCNK | O75909 | 1/20 | 0.36 |
| ▸ | CCND3 | P30281 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7083292 | 0.88 | SMN1; SMN2 (0.43) | PKMLRRK2SMN1; SMN2HTTLMNA | |
| SCHEMBL7080965 | 0.85 | SMN1; SMN2 (0.41) | PKMLRRK2SMN1; SMN2HTTLMNA | |
| SCHEMBL7090424 | 0.85 | ALDH1A1 (0.49) | PKMLRRK2SMN1; SMN2LMNANPSR1 | |
| SCHEMBL7087916 | 0.85 | CCR4 (0.39) | METAP2CCNA2CDK2CCNKCCND3 | |
| SCHEMBL5376795 | 0.81 | METAP2 (0.41) | PKMLRRK2SMN1; SMN2HTTLMNA | |
| SCHEMBL7084630 | 0.80 | MEN1 (0.42) | SMN1; SMN2LMNAMETAP2NPC1RAB9A | |
| SCHEMBL7088195 | 0.79 | NFKB1 (0.48) | HTTPOLBNPC1RAB9ACCNA2 | |
| SCHEMBL7085330 | 0.79 | LRRK2 (0.43) | LRRK2SMN1; SMN2HTTLMNANPSR1 | |
| SCHEMBL7089876 | 0.77 | SMN1; SMN2 (0.44) | PKMLRRK2SMN1; SMN2HTTLMNA | |
| SCHEMBL6985036 | 0.75 | PDE4B (0.43) | SMN1; SMN2LMNANPC1RAB9ACDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1223932-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2003-01-15 | — | — | EP | claimed |
| EP-1223932-A1 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2002-07-24 | — | — | EP | claimed |
| WO-2001024796-A1 | 1,2,4-TRIAZOLE DERIVATIVES, COMPOSITION, PROCESS OF MAKING AND METHODS OF USE | SMITHKLINE BEECHAM CORPORATION (US) | 2001-04-12 | — | — | WO | claimed |