Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 12/20 | 0.59 |
| ▸ | MMP9 | P14780 | 12/20 | 0.59 |
| ▸ | MMP8 | P22894 | 11/20 | 0.59 |
| ▸ | TAS2R14 | Q9NYV8 | 3/20 | 0.56 |
| ▸ | MMP13 | P45452 | 10/20 | 0.55 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.54 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.54 |
| ▸ | PTGES | O14684 | 1/20 | 0.54 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.54 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.54 |
| ▸ | BMP1 | P13497 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7089279 | 1.00 | MMP2 (0.59) | MMP2MMP9MMP8TAS2R14MMP13 | |
| SCHEMBL5451163 | 0.91 | TAS2R14 (0.64) | MMP2MMP9MMP8TAS2R14MMP13 | |
| SCHEMBL5097892 | 0.88 | MMP9 (0.62) | MMP2MMP9MMP8MMP13CXCR3 | |
| SCHEMBL7340794 | 0.88 | MMP9 (0.62) | MMP2MMP9MMP8MMP13CXCR3 | |
| SCHEMBL11956143 | 0.88 | BMP1 (0.54) | MMP2MMP9MMP8TAS2R14MMP13 | |
| SCHEMBL5463131 | 0.88 | BMP1 (0.54) | MMP2MMP9MMP8TAS2R14MMP13 | |
| SCHEMBL7091051 | 0.87 | MMP2 (0.76) | MMP2MMP9MMP8TAS2R14MMP13 | |
| SCHEMBL7091056 | 0.87 | MMP2 (0.76) | MMP2MMP9MMP8TAS2R14MMP13 | |
| SCHEMBL7091054 | 0.87 | MMP2 (0.76) | MMP2MMP9MMP8TAS2R14MMP13 | |
| SCHEMBL7345045 | 0.85 | TAS2R14 (0.54) | MMP2MMP9MMP8TAS2R14MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891328-B1 | PEPTIDYL COMPOUNDS HAVING MMP AND TNF INHIBITORY ACTIVITY | DARWIN DISCOVERY LTD (GB) | 2003-08-13 | — | — | EP | disclosed |
| US-6114372-A | MATRIX METALLOPROTEINASE (MMP); TUMOR NECROSIS FACTOR(TNF); COMPOUNDS SUCH AS N2-((2S)-ACETYLMERCAPTO)ACETYL-5-PHTHALIMIDOPENTANOYL)-N1-((4 -METHOXYBENZENE)SULPHONYL)-N1-(PHENYLMETHYL)HYDRAZINE | DARWIN DISCOVERY LIMITED (GB) | 2000-09-05 | — | — | US | disclosed |