Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 7/20 | 0.50 |
| ▸ | THRB | P10828 | 7/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.45 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.43 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7088959 | 0.84 | LTA4H (0.48) | THRATHRBFAAHMEN1KMT2A | |
| SCHEMBL7084815 | 0.83 | THRA (0.50) | THRATHRBFAAHMEN1KMT2A | |
| SCHEMBL7086847 | 0.83 | LTA4H (0.46) | THRATHRBFAAHMEN1KMT2A | |
| SCHEMBL7084248 | 0.82 | LTA4H (0.46) | THRATHRBFAAHMEN1KMT2A | |
| SCHEMBL7087739 | 0.81 | HTR1A (0.46) | THRATHRBFAAHMEN1KMT2A | |
| SCHEMBL7089347 | 0.81 | THRA (0.51) | THRATHRBFAAHMEN1KMT2A | |
| SCHEMBL7085460 | 0.81 | THRA (0.48) | THRATHRBFAAHMEN1KMT2A | |
| SCHEMBL7088540 | 0.80 | THRA (0.61) | THRATHRBFAAHMEN1KMT2A | |
| SCHEMBL7088551 | 0.79 | THRA (0.75) | THRATHRBNR1H2NR1H3 | |
| SCHEMBL7091904 | 0.78 | THRA (0.66) | THRATHRBHTR2ALTA4HPLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268422-A1 | INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES | Bayer Aktiengesellschaft (DE) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070687-A1 | INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES | BAYER AKTIENGESELLSCHAFT (DE) | 2001-09-27 | — | — | WO | disclosed |