Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 4/20 | 0.34 |
| ▸ | MMP3 | P08254 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7034791 | 0.83 | KDM4E (0.47) | GRIN1GRIN2BKCNH2ALDH1A1MEN1 | |
| SCHEMBL6995893 | 0.82 | KCNH2 (0.40) | KDM1AGRIN1GRIN2BKCNH2MMP2 | |
| SCHEMBL7033716 | 0.80 | KCNH2 (0.39) | KCNA5GRIN1GRIN2BKCNH2AOC3 | |
| SCHEMBL6992363 | 0.78 | KCNH2 (0.40) | KDM1AKCNH2MMP2MMP3MEN1 | |
| SCHEMBL6990334 | 0.78 | HRH2 (0.38) | KCNA5KDM1AGRIN1GRIN2BKCNH2 | |
| SCHEMBL6994724 | 0.77 | HRH2 (0.42) | KCNA5KDM1AKCNH2MEN1 | |
| SCHEMBL6987304 | 0.76 | MCHR1 (0.46) | KCNH2MMP2 | |
| SCHEMBL7035992 | 0.76 | KCNA5 (0.48) | KCNA5MEN1KMT2A | |
| SCHEMBL7092543 | 0.74 | MAPT (0.42) | KDM1AGRIN1GRIN2BKCNH2ALDH1A1 | |
| SCHEMBL7032240 | 0.74 | MEN1 (0.39) | KCNH2ALDH1A1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1301510-A1 | NEW BISPIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2003-04-16 | — | — | EP | disclosed |
| WO-2002004446-A1 | NEW BISPIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2002-01-17 | — | — | WO | disclosed |