SCHEMBL7090460

SCHEMBL7090460

[c]1cccc(Nc2c[c]ccc2)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 5/20 0.43
ALDH1A1 P00352 7/20 0.41
TDP1 Q9NUW8 5/20 0.41
ALOX12 P18054 4/20 0.41
L3MBTL1 Q9Y468 4/20 0.41
TSHR P16473 4/20 0.41
ALOX15 P16050 2/20 0.41
PTGS1 P23219 1/20 0.41
SLC6A2 P23975 1/20 0.41
MAPK1 P28482 1/20 0.41
PTGS2 P35354 1/20 0.41
HTR2B P41595 1/20 0.41
MAPT P10636 3/20 0.36
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
AR P10275 1/20 0.36
CYP3A4 P08684 5/20 0.33
HPGD P15428 3/20 0.33
HTT P42858 2/20 0.33
CYP1A2 P05177 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL226139 0.93 HSD17B10 (0.57) HSD17B10ALDH1A1TDP1ALOX12L3MBTL1
SCHEMBL2524839 0.85 HPGD (0.59) HSD17B10ALDH1A1TDP1ALOX12L3MBTL1
SCHEMBL2526849 0.85 RAD52 (0.45) HSD17B10ALDH1A1TDP1ALOX12L3MBTL1
SCHEMBL8715505 0.85 MEN1 (0.42) HSD17B10ALDH1A1TDP1ALOX12L3MBTL1
SCHEMBL8830220 0.85 ALOX12 (0.41) HSD17B10ALDH1A1TDP1ALOX12L3MBTL1
SCHEMBL11645558 0.85 MAPT (0.59) HSD17B10ALDH1A1TDP1ALOX12L3MBTL1
SCHEMBL29258302 0.83 ALDH1A1 (0.50) HSD17B10ALDH1A1TDP1ALOX12L3MBTL1
SCHEMBL2523436 0.82 NPSR1 (0.60) HSD17B10ALDH1A1MAPTMEN1KMT2A
SCHEMBL2529253 0.82 KIF11 (0.46) ALDH1A1L3MBTL1MAPK1MAPTKMT2A
SCHEMBL28875309 0.80 MAPT (0.61) HSD17B10ALDH1A1TDP1ALOX12L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109195573-B Oxidation hair dye composition 朋友株式会社 2022-12-13 CN disclosed
WO-2022231005-A1 OXIDATION HAIR DYE, FIRST AGENT FOR OXIDATION HAIR DYE, AND USAGE METHOD FOR OXIDATION HAIR DYE ホーユー株式会社 2022-11-03 WO disclosed
EP-3473238-B1 POWDER HAIR DYE COMPOSITION HOYU KK (JP) 2021-04-14 EP disclosed
WO-2020218588-A1 OXIDIATIVE DYE-CONTAINING COMPOSITION ホーユー株式会社 2020-10-29 WO disclosed
US-10729638-B2 Powder hair dye composition HOYU CO., LTD. (JP) 2020-08-04 US disclosed
EP-3015099-B1 HAIR COSMETIC MATERIAL, AND HAIR COSMETIC PRODUCT HOYU KK (JP) 2020-06-17 EP disclosed
US-20190328646-A1 POWDER HAIR DYE COMPOSITION HOYU CO., LTD. (JP) 2019-10-31 US disclosed
US-20190175461-A1 POWDER HAIR DYE COMPOSITION HOYU CO., LTD. (JP) 2019-06-13 US disclosed
EP-3473238-A1 POWDER HAIR DYE COMPOSITION Hoyu Co., Ltd. (JP) 2019-04-24 EP disclosed
EP-3473234-A1 POWDER HAIR DYE COMPOSITION Hoyu Co., Ltd. (JP) 2019-04-24 EP disclosed
EP-0117469-B2 Hair cosmetics KAO CORP (JP) 1996-09-04 EP disclosed
EP-0148466-B1 HAIR DYE COMPOSITIONS Kao Corporation (JP) 1990-03-07 EP disclosed
US-4839168-A PLANT EXTRACT AND POLYPEPTIDE COMPOUND KAO CORPORATION (JP) 1989-06-13 US disclosed
EP-0117469-B1 HAIR COSMETICS Kao Corporation (JP) 1988-04-20 EP disclosed
EP-0052489-B1 CATIONIC KERATIN DERIVATIVES, PROCESS OF THEIR PRODUCTION AND HAIR TREATING COSMETICS CONTAINING THEM KAO SOAP CO., LTD. (JP) 1985-07-24 EP disclosed
EP-0148466-A2 Hair dye compositions Kao Corporation (JP) 1985-07-17 EP disclosed
US-4517175-A FLAVANOL DERIVATIVES AND PROTEINS KAO CORPORATION (JP) 1985-05-14 US disclosed
EP-0117469-A1 Hair cosmetics Kao Corporation (JP) 1984-09-05 EP disclosed
US-4369037-A Hair treatment cosmetics containing cationic keratin derivatives KAO SOAP CO., LTD. (JP) 1983-01-18 US disclosed
EP-0052489-A2 Cationic keratin derivatives, process of their production and hair treating cosmetics containing them KAO SOAP CO., LTD. (JP) 1982-05-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10729638-B2 Powder hair dye composition SRD5A1, PYCR1, SRD5A2 HSD17B10 645/4885ALDH1A1 2249/4885TDP1 3127/4885
US-20190328646-A1 POWDER HAIR DYE COMPOSITION SRD5A1, PYCR1, SRD5A2 HSD17B10 645/4885ALDH1A1 2249/4885TDP1 3127/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.