Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27363641 | 0.86 | TDP1 (0.49) | TDP1L3MBTL1LMNAALDH1A1TSHR | |
| SCHEMBL11863178 | 0.82 | ALDH1A1 (0.45) | TDP1L3MBTL1LMNAALDH1A1TSHR | |
| SCHEMBL5209949 | 0.80 | L3MBTL1 (0.55) | TDP1L3MBTL1LMNAALDH1A1TSHR | |
| SCHEMBL11785469 | 0.77 | LMNA (0.47) | TDP1L3MBTL1LMNAALDH1A1TSHR | |
| SCHEMBL5204140 | 0.77 | PPARG (0.46) | TDP1L3MBTL1LMNAALDH1A1TSHR | |
| SCHEMBL11778290 | 0.77 | KMT2A (0.45) | TDP1L3MBTL1LMNAALDH1A1MAPK1 | |
| SCHEMBL5210241 | 0.77 | PPARA (0.48) | TDP1LMNAALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL14440810 | 0.76 | LMNA (0.46) | TDP1L3MBTL1LMNASMN1; SMN2ACHE | |
| SCHEMBL14234150 | 0.75 | LMNA (0.52) | TDP1L3MBTL1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL14233586 | 0.75 | LMNA (0.52) | TDP1L3MBTL1LMNAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339688-A1 | N-TYPE CALCIUM CHANNEL ANTAGONISTS FOR THE TREATMENT OF PAIN | AstraZeneca AB (SE) | 2003-09-03 | — | — | EP | disclosed |
| WO-2002036567-A1 | N-TYPE CALCIUM CHANNEL ANTAGONISTS FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2002-05-10 | — | — | WO | disclosed |