Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ME3 | Q16798 | 1/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7086594 | 0.83 | KDM4E (0.65) | LMNAEPHX2MAPTNPC1SMN1; SMN2 | |
| SCHEMBL7902716 | 0.82 | TP53 (0.60) | ME3SIGMAR1TDP1MAPTNPC1 | |
| SCHEMBL27904589 | 0.80 | SIGMAR1 (0.60) | SIGMAR1EPHX2EPHX1MAOAMAOB | |
| Benzene SCHEMBL27559018 | 0.80 | KDM1A (0.53) | ME3SIGMAR1EPHX2SMN1; SMN2MAOB | |
| SCHEMBL4180735 | 0.80 | EPHX2 (0.69) | SIGMAR1EPHX2EPHX1 | |
| SCHEMBL6190799 | 0.80 | ALDH1A1 (0.58) | ME3SIGMAR1EPHX1CHRM4 | |
| SCHEMBL15533318 | 0.79 | SIGMAR1 (0.59) | SIGMAR1EPHX2EPHX1MAOAMAOB | |
| SCHEMBL27557817 | 0.79 | ITGB3 (0.51) | ME3SIGMAR1EPHX2SMN1; SMN2MAOB | |
| SCHEMBL5504017 | 0.78 | SIGMAR1 (0.82) | SIGMAR1EPHX2EPHX1MAOAMAOB | |
| SCHEMBL28554753 | 0.77 | EPHX2 (0.80) | EPHX2EPHX1NPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341755-A1 | CARBOXYLIC ACID AMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF THROMBOEMBOLIC DISEASES AND TUMOURS | MERCK PATENT GmbH (DE) | 2003-09-10 | — | — | EP | disclosed |
| WO-2002048099-A1 | CARBOXYLIC ACID AMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF THROMBOEMBOLIC DISEASES AND TUMOURS | MERCK PATENT GMBH (DE) | 2002-06-20 | — | — | WO | disclosed |