Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 5/20 | 0.35 |
| ▸ | TUBB | P07437 | 5/20 | 0.35 |
| ▸ | TUBA3C | P0DPH7 | 5/20 | 0.35 |
| ▸ | TUBA1B | P68363 | 5/20 | 0.35 |
| ▸ | TUBA4A | P68366 | 5/20 | 0.35 |
| ▸ | TUBB4B | P68371 | 5/20 | 0.35 |
| ▸ | TUBB3 | Q13509 | 5/20 | 0.35 |
| ▸ | TUBB2A | Q13885 | 5/20 | 0.35 |
| ▸ | TUBB8 | Q3ZCM7 | 5/20 | 0.35 |
| ▸ | TUBA3E | Q6PEY2 | 5/20 | 0.35 |
| ▸ | TUBA1A | Q71U36 | 5/20 | 0.35 |
| ▸ | TUBA1C | Q9BQE3 | 5/20 | 0.35 |
| ▸ | TUBB6 | Q9BUF5 | 5/20 | 0.35 |
| ▸ | TUBB2B | Q9BVA1 | 5/20 | 0.35 |
| ▸ | TUBB1 | Q9H4B7 | 5/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7089403 | 0.88 | ADORA3 (0.45) | TNFRSF1ATUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL7090554 | 0.87 | NPSR1 (0.37) | HTTCNR1CNR2MEN1KMT2A | |
| SCHEMBL7085577 | 0.84 | CES2 (0.49) | TNFRSF1ATUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL7090216 | 0.83 | CTSA (0.36) | TNFRSF1ATUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL7133865 | 0.80 | RAB9A (0.46) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL7087485 | 0.77 | PTGS2 (0.47) | — | |
| SCHEMBL7090550 | 0.73 | AKR1C3 (0.37) | TNFRSF1AHTTCTSAADORA3KDM4E | |
| SCHEMBL7085135 | 0.72 | TNF (0.39) | TNFRSF1AHTTKDM4EALDH1A1HPGD | |
| SCHEMBL7091319 | 0.71 | TTR (0.34) | CTSAKDM4E | |
| SCHEMBL7089475 | 0.69 | AKR1C3 (0.33) | HTTMEN1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030050330-A1 | 4,5-subtstituted imdazolyl compounds for the treatment of inflammation | G.D. SEARLE & CO. | 2003-03-13 | — | — | US | disclosed |
| EP-0772601-B1 | 4,5-SUBSTITUTED IMIDAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2002-09-18 | — | — | EP | disclosed |
| US-6426360-B1 | ANTIARTHRITIC AGENTS | G D SEARLE & CO. | 2002-07-30 | — | — | US | disclosed |
| EP-1211244-A2 | 4,5-substitued imidazolyl compounds for the treatment of inflammation | G.D. Searle & Co. (US) | 2002-06-05 | — | — | EP | disclosed |
| WO-1996003387-A1 | 4,5-SUBSTITUTED IMIDAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030050330-A1 | 4,5-subtstituted imdazolyl compounds for the treatment of inflammation | AHR, HACL2, IRAK2 | TNFRSF1A 2663/4885TUBB4A 3197/4885TUBB 3235/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.