SCHEMBL7092322

SCHEMBL7092322

Nc1cc(=O)[nH]c(=O)n1Cc1cccc(Cl)c1

nearest known ligand 0.75

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.75
ALDH1A1 P00352 2/20 0.75
HPGD P15428 1/20 0.75
MTNR1A P48039 2/20 0.65
MTNR1B P49286 2/20 0.65
KMT2A Q03164 4/20 0.55
L3MBTL1 Q9Y468 1/20 0.55
TSHR P16473 1/20 0.55
PGR P06401 2/20 0.50
MAPT P10636 3/20 0.48
CYP2C9 P11712 1/20 0.48
CYP2C19 P33261 1/20 0.48
MEN1 O00255 2/20 0.47
USP2 O75604 1/20 0.47
LMNA P02545 1/20 0.47
KDM4E B2RXH2 1/20 0.47
MAPK1 P28482 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
TLR7 Q9NYK1 1/20 0.46
GRIN1 Q05586 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7679940 0.86 ALDH1A1 (0.77) CYP3A4ALDH1A1HPGDMTNR1AMTNR1B
SCHEMBL1032784 0.86 HPGD (1.00) CYP3A4ALDH1A1HPGDMTNR1AMTNR1B
SCHEMBL7088588 0.79 ALDH1A1 (0.74) CYP3A4ALDH1A1HPGDMTNR1AMTNR1B
SCHEMBL1944502 0.77 ALDH1A1 (0.70) CYP3A4ALDH1A1HPGDMTNR1AMTNR1B
SCHEMBL7969932 0.75 MTNR1A (0.76) CYP3A4ALDH1A1HPGDMTNR1AMTNR1B
SCHEMBL7091654 0.75 MAPT (0.49) CYP3A4ALDH1A1HPGDKMT2APGR
SCHEMBL4920376 0.73 LMNA (0.76) CYP3A4ALDH1A1HPGDKMT2APGR
SCHEMBL8578072 0.73 KMT2A (0.76) CYP3A4ALDH1A1HPGDMTNR1AMTNR1B
SCHEMBL7325383 0.73 MTNR1A (0.68) CYP3A4ALDH1A1HPGDMTNR1AMTNR1B
SCHEMBL25130124 0.71 HPGD (0.68) CYP3A4ALDH1A1HPGDMTNR1AMTNR1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0814809-B1 ARYL THIOXANTHINES EURO CELTIQUE SA (LU) 2003-08-13 EP disclosed
US-6440979-B1 Aryl isoguanines EURO-CELTIQUE, S.A. (LU) 2002-08-27 US disclosed
US-6090816-A ANTIASTHMA AGENTS EURO-CELTIQUE S.A. (LU) 2000-07-18 US disclosed
US-6066641-A PHOSPHODIESTERASES AS MOLECULAR TARGETS FOR ANTI-ASTHMATIC AGENTS EURO-CELTIQUE S.A. (LU) 2000-05-23 US disclosed
EP-0814809-A4 ARYL THIOXANTHINES EURO CELTIQUE SA (LU) 1998-04-01 EP disclosed
EP-0814809-A1 ARYL THIOXANTHINES Euroceltique S.A. (LU) 1998-01-07 EP disclosed
WO-1996018399-A1 ARYL THIOXANTHINES EURO-CELTIQUE, S.A. (LU) 1996-06-20 WO disclosed