Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.56 |
| ▸ | F7 | P08709 | 1/20 | 0.56 |
| ▸ | F3 | P13726 | 1/20 | 0.56 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.56 |
| ▸ | RHEB | Q15382 | 2/20 | 0.50 |
| ▸ | EIF4A3 | P38919 | 3/20 | 0.49 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22747199 | 0.93 | GPR35 (0.56) | GPR35F7F3PIN1RHEB | |
| SCHEMBL7682186 | 0.85 | GPR35 (0.63) | GPR35F7F3PIN1EIF4A3 | |
| SCHEMBL3641952 | 0.85 | GPR35 (0.63) | GPR35F7F3PIN1RHEB | |
| SCHEMBL8622921 | 0.84 | GPR35 (0.61) | GPR35F7F3PIN1RHEB | |
| SCHEMBL7040376 | 0.81 | GPR35 (0.73) | GPR35F7F3PIN1EIF4A3 | |
| SCHEMBL4049040 | 0.80 | ALOX15 (0.66) | HPGDKDM4EHSD17B10ALDH1A1LMNA | |
| SCHEMBL765246 | 0.79 | EIF4A3 (0.60) | GPR35F7F3PIN1EIF4A3 | |
| SCHEMBL3639230 | 0.79 | EIF4A3 (0.60) | GPR35F7F3PIN1RHEB | |
| SCHEMBL13173649 | 0.79 | SRD5A2 (0.56) | GPR35F7F3PIN1RHEB | |
| SCHEMBL1822084 | 0.77 | ALOX15 (0.56) | GPR35F7F3PIN1RHEB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1277828-C | Piperzine devivs. | HOFFMANN LA ROCHE (CH) | 2006-10-04 | — | — | CN | disclosed |
| CN-1245405-C | Piperazine derivatives | HOFFMANN LA ROCHE (CH) | 2006-03-15 | — | — | CN | disclosed |
| CN-1529706-A | Piperazine derivatives | - | 2004-09-15 | — | — | CN | disclosed |
| CN-1452622-A | Piperzine devivs. | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | CN | disclosed |
| EP-1325008-A1 | PIPERAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-07-09 | — | — | EP | disclosed |
| WO-2002010169-A1 | PIPERAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-02-07 | — | — | WO | disclosed |