Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 20/20 | 0.69 |
| ▸ | HTR2A | P28223 | 18/20 | 0.69 |
| ▸ | HTR2B | P41595 | 5/20 | 0.56 |
| ▸ | HTR1A | P08908 | 2/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.56 |
| ▸ | HTR1D | P28221 | 1/20 | 0.56 |
| ▸ | HTR7 | P34969 | 1/20 | 0.56 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7995866 | 1.00 | HTR2C (0.69) | HTR2CHTR2AHTR2BHTR1AADRA2A | |
| SCHEMBL7998321 | 1.00 | HTR2C (0.69) | HTR2CHTR2AHTR2BHTR1AADRA2A | |
| Fumaric Acid SCHEMBL7091553 | 0.89 | HTR2C (0.57) | HTR2CHTR2AHTR2BHTR1AADRA2A | |
| Fumaric Acid SCHEMBL7091552 | 0.89 | HTR2C (0.57) | HTR2CHTR2AHTR2BHTR1AADRA2A | |
| SCHEMBL8001801 | 0.88 | HTR2C (0.67) | HTR2CHTR2AHTR2BHTR1AADRA2A | |
| SCHEMBL8001799 | 0.88 | HTR2C (0.67) | HTR2CHTR2AHTR2BHTR1AADRA2A | |
| SCHEMBL9230485 | 0.82 | HTR2C (1.00) | HTR2CHTR2AHTR2BHTR7CYP1A2 | |
| SCHEMBL9230483 | 0.82 | HTR2C (1.00) | HTR2CHTR2AHTR2BHTR7CYP1A2 | |
| SCHEMBL7997689 | 0.81 | HTR2C (0.77) | HTR2CHTR2AHTR2BHTR7CYP1A2 | |
| SCHEMBL8959602 | 0.81 | HTR2C (1.00) | HTR2CHTR2AHTR2BCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030114512-A1 | Compounds with 5-ht2 and 5-ht1a agonist activity for treating glaucoma | ALCON UNIVERSAL LTD. (CH) | 2003-06-19 | — | — | US | claimed |
| EP-1263434-A1 | COMPOUNDS WITH 5-HT 2 AND 5-HT 1A AGONIST ACTIVITY FOR TREATING GLAUCOMA | Alcon, Inc (CH) | 2002-12-11 | — | — | EP | claimed |
| WO-2001070223-A1 | COMPOUNDS WITH 5-HT2 AND 5-HT1A AGONIST ACTIVITY FOR TREATING GLAUCOMA | ALCON, INC. (CH) | 2001-09-27 | — | — | WO | claimed |
| WO-2001040183-A1 | 1-AMINOALKYL-1H-INDOLES FOR TREATING GLAUCOMA | ALCON UNIVERSAL LTD. (CH) | 2001-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030114512-A1 | Compounds with 5-ht2 and 5-ht1a agonist activity for treating glaucoma | HTR1A, HTR2A, HTR5A | HTR2C 6/4885HTR2A 2/4885HTR2B 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.