Fumaric Acid — predicted protein targets

Known targets — ChEMBL curated mechanism

ACE ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 ATP4A ATP4B AXL BTK CACNA1C CACNA1D CACNA1F CACNA1S CCR5 CHRM2 CHRM3 CPT1B CPT2 DPP4 DRD1 DRD2 EGFR ERBB2 ERBB4 FLT3 HRH1 HRH3 HTR1A HTR2A HTR2B HTR2C HTR4 JAK1 JAK2 JAK3 KCNH2 KMT2A MAP2K1 MAP2K2 MEN1 MLNR MPL MTOR P PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PLK4 PPARG REN S1PR1 SLC6A2 SLC6A3 SLC6A4 SMO TYK2 atpA atpB atpC atpD atpE atpF atpFH atpG pol

The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 19)

	gene	UniProt	supporting neighbours	confidence
▸	HTR2C known ✓	P28335	16/20	0.57

▸	HTR2A known ✓	P28223	14/20	0.57

▸	HTR2B known ✓	P41595	3/20	0.47

▸	HTR1A known ✓	P08908	2/20	0.47

▸	ADRA2A known ✓	P08913	2/20	0.47

▸	ADRA2B known ✓	P18089	2/20	0.47

▸	ADRA2C known ✓	P18825	2/20	0.47

▸	HTR4 known ✓	Q13639	1/20	0.47

▸	HTR1D	P28221	1/20	0.47

▸	HTR7	P34969	1/20	0.47

▸	CYP1A2	P05177	1/20	0.46

▸	CYP3A4	P08684	1/20	0.46

▸	CYP2C9	P11712	1/20	0.46

▸	NPSR1	Q6W5P4	2/20	0.44

▸	BLM	P54132	1/20	0.44

▸	BACE1	P56817	1/20	0.41

▸	LMNA	P02545	1/20	0.40

▸	PMP22	Q01453	1/20	0.40

▸	GFER	P55789	1/20	0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Fumaric Acid SCHEMBL7091552	1.00	HTR2C (0.57)	HTR2CHTR2AHTR2BHTR1AADRA2A
SCHEMBL7998321	0.89	HTR2C (0.69)	HTR2CHTR2AHTR2BHTR1AADRA2A
SCHEMBL7995866	0.89	HTR2C (0.69)	HTR2CHTR2AHTR2BHTR1AADRA2A
SCHEMBL7092848	0.89	HTR2C (0.69)	HTR2CHTR2AHTR2BHTR1AADRA2A
Fumaric Acid SCHEMBL8959577	0.87	HTR2C (0.77)	HTR2CHTR2AHTR2BCYP1A2CYP3A4
Fumaric Acid SCHEMBL8959584	0.87	HTR2C (0.77)	HTR2CHTR2AHTR2BCYP1A2CYP3A4
Fumaric Acid SCHEMBL8959556	0.86	HTR2C (0.78)	HTR2CHTR2AHTR2BCYP1A2CYP3A4
Fumaric Acid SCHEMBL7997834	0.86	HTR2C (0.61)	HTR2CHTR2AHTR2BCYP1A2CYP3A4
Fumaric Acid SCHEMBL8959564	0.86	HTR2C (0.78)	HTR2CHTR2AHTR2BCYP1A2CYP3A4
Fumaric Acid SCHEMBL7997829	0.86	HTR2C (0.61)	HTR2CHTR2AHTR2BCYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-20030114512-A1	Compounds with 5-ht2 and 5-ht1a agonist activity for treating glaucoma	ALCON UNIVERSAL LTD. (CH)	2003-06-19	—	—	US	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20030114512-A1	Compounds with 5-ht2 and 5-ht1a agonist activity for treating glaucoma	HTR1A, HTR2A, HTR5A	HTR2C 6/4885HTR2A 2/4885HTR2B 13/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.