Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | IDH2 | P48735 | 7/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.42 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.42 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.42 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7090802 | 0.84 | KIF11 (0.45) | KIF11KDM4EMAPTIDH2LMNA | |
| SCHEMBL5492399 | 0.76 | DCUN1D1 (0.46) | KDM4E | |
| SCHEMBL1921482 | 0.72 | KIF11 (0.70) | KIF11MAPTIDH2 | |
| SCHEMBL394991 | 0.72 | KIF11 (0.70) | KIF11KDM4EMAPTIDH2LMNA | |
| SCHEMBL7090723 | 0.69 | KIF11 (0.49) | KIF11MAPTIDH2 | |
| SCHEMBL16411339 | 0.69 | KIF11 (0.65) | KIF11KDM4EMAPTIDH2MEN1 | |
| SCHEMBL1921505 | 0.68 | KIF11 (0.64) | KIF11MAPTIDH2 | |
| SCHEMBL30575363 | 0.68 | IDH2 (0.77) | KIF11KDM4EMAPTIDH2MEN1 | |
| SCHEMBL7347670 | 0.68 | IDH2 (0.77) | KIF11KDM4EMAPTIDH2MEN1 | |
| SCHEMBL8102983 | 0.67 | MAPT (0.53) | MAPTIDH2LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1363897-A2 | ANTAGONISTS OF MCP-1 FUNCTION AND METHODS OF USE THEREOF | TELIK, INC. (US) | 2003-11-26 | — | — | EP | disclosed |
| WO-2002070509-A2 | ANTAGONISTS OF MCP-1 FUNCTION AND METHODS OF USE THEREOF | TELIK, INC. (US) | 2002-09-12 | — | — | WO | disclosed |