Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.56 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 14/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 8/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7734184 | 0.90 | GAA (0.61) | MTNR1AMTNR1BPDE4BGAAMAPK1 | |
| SCHEMBL7325383 | 0.86 | MTNR1A (0.68) | MTNR1AMTNR1BGAAMAPK1ALDH1A1 | |
| SCHEMBL7092242 | 0.86 | MTNR1A (0.57) | MTNR1AMTNR1BPDE4BGAAMAPK1 | |
| SCHEMBL7088468 | 0.81 | PDE4B (0.48) | PDE4BALDH1A1HPGDPDE4APDE4C | |
| SCHEMBL6673366 | 0.78 | PDE4B (0.48) | PDE4BGAAMAPK1PDE4APDE4C | |
| SCHEMBL7676935 | 0.77 | PDE4B (0.48) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7556840 | 0.77 | PDE4B (0.55) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7092998 | 0.76 | PDE4B (0.60) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7088560 | 0.76 | KDM4E (0.50) | PDE4BALDH1A1HPGDPDE4APDE4C | |
| SCHEMBL7031802 | 0.75 | PDE4B (0.45) | PDE4BGAAMAPK1PDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0814809-B1 | ARYL THIOXANTHINES | EURO CELTIQUE SA (LU) | 2003-08-13 | — | — | EP | disclosed |
| US-6440979-B1 | Aryl isoguanines | EURO-CELTIQUE, S.A. (LU) | 2002-08-27 | — | — | US | disclosed |
| US-6090816-A | ANTIASTHMA AGENTS | EURO-CELTIQUE S.A. (LU) | 2000-07-18 | — | — | US | disclosed |
| US-6066641-A | PHOSPHODIESTERASES AS MOLECULAR TARGETS FOR ANTI-ASTHMATIC AGENTS | EURO-CELTIQUE S.A. (LU) | 2000-05-23 | — | — | US | disclosed |
| EP-0814809-A4 | ARYL THIOXANTHINES | EURO CELTIQUE SA (LU) | 1998-04-01 | — | — | EP | disclosed |
| EP-0814809-A1 | ARYL THIOXANTHINES | Euroceltique S.A. (LU) | 1998-01-07 | — | — | EP | disclosed |
| WO-1996018399-A1 | ARYL THIOXANTHINES | EURO-CELTIQUE, S.A. (LU) | 1996-06-20 | — | — | WO | disclosed |