Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 19/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 7/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7734184 | 0.81 | GAA (0.61) | PDE4BPDE3APDE4APDE4CPDE4D | |
| SCHEMBL6673366 | 0.78 | PDE4B (0.48) | PDE4BPDE3APDE4APDE4CPDE4D | |
| SCHEMBL7337524 | 0.77 | MPO (0.55) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7556832 | 0.77 | PDE4B (0.55) | PDE4BPDE3APDE4APDE4CPDE4D | |
| SCHEMBL7093510 | 0.77 | MTNR1A (0.56) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7031802 | 0.75 | PDE4B (0.45) | PDE4BPDE3APDE4APDE4CPDE4D | |
| SCHEMBL7676935 | 0.75 | PDE4B (0.48) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL8655603 | 0.75 | PDE4B (0.48) | PDE4BPDE3APDE4APDE4CPDE4D | |
| SCHEMBL27495378 | 0.74 | PDE4B (0.57) | PDE4B | |
| SCHEMBL7336596 | 0.74 | PDE4B (0.47) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1169321-A4 | PURINE DERIVATIVES HAVING PHOSPHODIESTERASE IV INHIBITION ACTIVITY | EURO CELTIQUE SA (LU) | 2002-10-30 | — | — | EP | disclosed |
| EP-1169321-A2 | PURINE DERIVATIVES HAVING PHOSPHODIESTERASE IV INHIBITION ACTIVITY | Euro-Celtique S.A. (LU) | 2002-01-09 | — | — | EP | disclosed |
| WO-2000059449-A2 | PURINE DERIVATIVES HAVING PHOSPHODIESTERASE IV INHIBITION ACTIVITY | EURO-CELTIQUE S.A. (LU) | 2000-10-12 | — | — | WO | disclosed |