Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | TDO2 | P48775 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7092760 | 0.92 | HTR2A (0.43) | IDO1TDO2HTR2ATAAR1SLC6A2 | |
| SCHEMBL7093907 | 0.83 | HTR2A (0.56) | HTR2ATAAR1SLC6A2SLC6A4MEN1 | |
| SCHEMBL7093914 | 0.82 | TAAR1 (0.52) | HTR2ATAAR1SLC6A2SLC6A4 | |
| SCHEMBL7093892 | 0.81 | SLC6A2 (0.45) | HTR2ATAAR1SLC6A2SLC6A4 | |
| SCHEMBL7094120 | 0.78 | SLC6A2 (0.41) | HTR2ATAAR1SLC6A2SLC6A4MEN1 | |
| SCHEMBL3902718 | 0.77 | HTR2A (0.68) | IDO1TDO2HTR2ATAAR1KIF11 | |
| SCHEMBL7090263 | 0.74 | CYP3A4 (0.50) | HTR2ATAAR1SLC6A2SLC6A4 | |
| SCHEMBL11078413 | 0.72 | IDO1 (0.52) | IDO1TDO2HTR2ATAAR1 | |
| SCHEMBL7093212 | 0.72 | NR3C1 (0.54) | — | |
| SCHEMBL7093895 | 0.71 | IDO1 (0.44) | IDO1TDO2MTNR1AMTNR1BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003082777-A2 | NOVEL GLUCOCORTICOID RECEPTOR LIGANDS | KARO BIO AB (SE) | 2003-10-09 | — | — | WO | claimed |
| WO-2003082777-A2 | NOVEL GLUCOCORTICOID RECEPTOR LIGANDS | KARO BIO AB (SE) | 2003-10-09 | — | — | WO | disclosed |