Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.48 |
| ▸ | CTSV | O60911 | 2/20 | 0.44 |
| ▸ | CTSL | P07711 | 2/20 | 0.44 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30702565 | 0.83 | HTR2A (0.49) | CHRNA7HTR1AHTR2AHTR2C | |
| SCHEMBL29144623 | 0.83 | HTR2A (0.49) | CHRNA7HTR1AHTR2AHTR2C | |
| SCHEMBL5762667 | 0.83 | CHRNA7 (0.55) | CHRNA7CTSVCTSLREV1PDE4A | |
| Hydrochloric Acid SCHEMBL7092902 | 0.76 | MEN1 (0.40) | — | |
| SCHEMBL5564105 | 0.76 | MAOA (0.49) | CHRNA7HTR2AHTR2C | |
| SCHEMBL3055592 | 0.75 | CHRNA7 (0.52) | CHRNA7CTSVCTSLHTR1AHTR2A | |
| SCHEMBL7752192 | 0.75 | HTR7 (0.42) | HTR2AHTR2C | |
| SCHEMBL3051568 | 0.74 | CHRNA7 (0.60) | CHRNA7CTSVCTSLREV1HTR2A | |
| SCHEMBL6634111 | 0.74 | CHRNA7 (0.60) | CHRNA7CTSVCTSLREV1HTR2A | |
| SCHEMBL3056405 | 0.73 | MAOA (0.62) | CHRNA7CTSVCTSLPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309551-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002014273-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-02-21 | — | — | WO | disclosed |