Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL910444 | 0.77 | MMP12 (0.44) | — | |
| SCHEMBL1744894 | 0.76 | ALDH1A1 (0.39) | BRD4 | |
| SCHEMBL3865428 | 0.72 | DDB1 (0.38) | RAB9ABRD4 | |
| SCHEMBL22347139 | 0.68 | HDAC4 (0.42) | HDAC4NOTUMPIK3CAPIK3CGNPC1 | |
| SCHEMBL1450577 | 0.68 | PARP1 (0.60) | BRD4 | |
| SCHEMBL20278 | 0.66 | CTNNB1 (0.31) | NOTUMPIK3CAPIK3CGNPC1RAB9A | |
| SCHEMBL3252263 | 0.64 | PARP1 (0.33) | — | |
| SCHEMBL4267781 | 0.63 | KDM4E (0.52) | NPC1 | |
| SCHEMBL2481715 | 0.63 | JAK1 (0.31) | — | |
| SCHEMBL17634194 | 0.63 | CA2 (0.40) | BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1359908-A1 | QUINOLINES AND NITROGENATED DERIVATIVES THEREOF SUBSTITUTED IN 4-POSITION BY A PIPERIDINE-CONTAINING MOIETY AND THEIR USE AS ANTIBACTERIAL AGENTS | SMITHKLINE BEECHAM PLC (GB) | 2003-11-12 | — | — | EP | claimed |
| WO-2002056882-A1 | QUINOLINES AND NITROGENATED DERIVAIVE THEREOF SUBSTITUTED IN 4-POSITION BY A PIPERIDINE-CONTAINING MOIETY AND THEIR USE AS ANTIBACTERIAL AGENTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-07-25 | — | — | WO | claimed |