Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.48 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.48 |
| ▸ | HINT1 | P49773 | 9/20 | 0.46 |
| ▸ | TYMP | P19971 | 5/20 | 0.45 |
| ▸ | GSK3A | P49840 | 2/20 | 0.43 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | PNP | P00491 | 1/20 | 0.41 |
| ▸ | NT5E | P21589 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7644145 | 0.86 | TAAR1 (0.44) | TAS1R3TAS1R1HINT1GSK3ARPS6KA3 | |
| SCHEMBL313746 | 0.85 | TYMP (0.62) | TAS1R3TAS1R1HINT1TYMPGSK3A | |
| SCHEMBL313747 | 0.85 | TYMP (0.62) | TAS1R3TAS1R1HINT1TYMPGSK3A | |
| SCHEMBL7201354 | 0.80 | TYMP (0.62) | TAS1R3TAS1R1HINT1TYMPGSK3A | |
| SCHEMBL29673061 | 0.78 | TYMP (0.44) | TAS1R3TAS1R1HINT1TYMPTAAR1 | |
| SCHEMBL34234 | 0.77 | TYMP (0.64) | TAS1R3TAS1R1HINT1TYMPGSK3A | |
| SCHEMBL312927 | 0.76 | HINT1 (0.59) | TAS1R3TAS1R1HINT1GSK3ARPS6KA3 | |
| SCHEMBL312926 | 0.76 | HINT1 (0.59) | TAS1R3TAS1R1HINT1GSK3ARPS6KA3 | |
| SCHEMBL31611267 | 0.76 | TAS1R3 (0.42) | TAS1R3TAS1R1HINT1TYMPTAAR1 | |
| SCHEMBL1738400 | 0.76 | TYMP (0.68) | TAS1R3TAS1R1HINT1TYMPGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030224513-A1 | Antisense modulation of Notch1 expression | ISIS PHARMACEUTICALS INC. | 2003-12-04 | — | — | US | disclosed |
| WO-2003099840-A1 | OLIGONUCLEOTIDES HAVING MODIFIED NUCLEOSIDE UNITS | ISIS PHARMACEUTICALS, INC. (US) | 2003-12-04 | — | — | WO | disclosed |