Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.44 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
| ▸ | HINT1 | P49773 | 9/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 2/20 | 0.37 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PNP | P00491 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7095544 | 0.86 | TAS1R3 (0.48) | TAAR1TAS1R3TAS1R1HINT1GSK3A | |
| SCHEMBL7647098 | 0.85 | TAAR1 (0.47) | TAAR1TAS1R3TAS1R1HINT1ALDH1A1 | |
| SCHEMBL9790922 | 0.75 | ADORA1 (0.49) | KMT2A | |
| SCHEMBL10904154 | 0.74 | TAAR1 (0.57) | TAAR1HINT1GSK3ARPS6KA3MAPK14 | |
| SCHEMBL7100209 | 0.73 | TYMP (0.54) | TAAR1HINT1GSK3ARPS6KA3MAPK14 | |
| SCHEMBL313746 | 0.73 | TYMP (0.62) | TAS1R3TAS1R1HINT1GSK3ARPS6KA3 | |
| SCHEMBL313747 | 0.73 | TYMP (0.62) | TAS1R3TAS1R1HINT1GSK3ARPS6KA3 | |
| SCHEMBL312926 | 0.72 | HINT1 (0.59) | TAS1R3TAS1R1HINT1ALDH1A1GSK3A | |
| SCHEMBL312927 | 0.72 | HINT1 (0.59) | TAS1R3TAS1R1HINT1ALDH1A1GSK3A | |
| SCHEMBL8669174 | 0.71 | TAAR1 (0.51) | TAAR1HINT1GSK3ARPS6KA3MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6498035-B1 | METHODS ARE PROVIDED FOR MODULATING THE EXPRESSION OF MEKK3. THE COMPOSITIONS COMPRISE ANTISENSE COMPOUNDS, PARTICULARLY ANTISENSE OLIGONUCLEOTIDES, TARGETED TO NUCLEIC ACIDS ENCODING MEKK3. | ISIS PHARMACEUTICALS, INC. | 2002-12-24 | — | — | US | disclosed |