Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7099393 | 0.81 | SIGMAR1 (0.44) | SIGMAR1KMT2AALDH1A1MAPK1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL6775782 | 0.80 | SIGMAR1 (0.43) | SIGMAR1KMT2AALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL7103386 | 0.80 | SIGMAR1 (0.57) | SIGMAR1KMT2AALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL6774554 | 0.79 | SIGMAR1 (0.87) | SIGMAR1KMT2AALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL7099090 | 0.77 | SIGMAR1 (0.53) | SIGMAR1KMT2AMAPK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL8331768 | 0.76 | ALDH1A1 (0.57) | SIGMAR1KMT2AALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL6769888 | 0.75 | SIGMAR1 (0.53) | SIGMAR1KMT2AMAPK1SMN1; SMN2MAPT | |
| SCHEMBL7105259 | 0.74 | KMT2A (0.55) | SIGMAR1KMT2AMAPK1SMN1; SMN2MAPT | |
| SCHEMBL6775648 | 0.72 | SIGMAR1 (0.72) | SIGMAR1KMT2AALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL7100164 | 0.72 | SIGMAR1 (0.61) | SIGMAR1KMT2AALDH1A1L3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030153763-A1 | Pharmaceutically active compounds and methods of use | WYETH | 2003-08-14 | — | — | US | claimed |
| US-20020099084-A1 | Pharmaceutically active compounds and methods of use | WYETH | 2002-07-25 | — | — | US | claimed |
| WO-1999002145-A1 | COMBINATION DRUG THERAPIES COMPRISING AMINOGLYCOSIDE ANTIBIOTICS AND N,N'-DISUBSTITUTED GUANIDINES | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1999-01-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030153763-A1 | Pharmaceutically active compounds and methods of use | ACHE, PARK7, NLN | SIGMAR1 2813/4885KMT2A 3542/4885ALDH1A1 479/4885 |
| US-20020099084-A1 | Pharmaceutically active compounds and methods of use | ACHE, PARK7, NLN | SIGMAR1 2813/4885KMT2A 3542/4885ALDH1A1 479/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.