Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.59 |
| ▸ | NOS1 | P29475 | 7/20 | 0.42 |
| ▸ | NOS2 | P35228 | 6/20 | 0.42 |
| ▸ | NOS3 | P29474 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.41 |
| ▸ | DDAH1 | O94760 | 3/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ARG2 | P78540 | 4/20 | 0.39 |
| ▸ | ARG1 | P05089 | 3/20 | 0.39 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.38 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.38 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL25176285 | 0.95 | GSR (0.65) | GSRNOS1NOS2NOS3CYP1A2 | |
| Lysine SCHEMBL29170023 | 0.86 | GSR (0.74) | GSRNOS1NOS2NOS3CYP1A2 | |
| Lysine SCHEMBL28599698 | 0.86 | GSR (0.74) | GSRNOS1NOS2NOS3CYP1A2 | |
| Lysine SCHEMBL29244084 | 0.86 | GSR (0.74) | GSRNOS1NOS2NOS3CYP1A2 | |
| Lysine SCHEMBL28697152 | 0.86 | GSR (0.80) | GSRNOS1NOS2NOS3CYP1A2 | |
| Lysine SCHEMBL50314 | 0.86 | GSR (0.80) | GSRNOS1NOS2NOS3CYP1A2 | |
| Lysine SCHEMBL28241453 | 0.86 | GSR (0.80) | GSRNOS1NOS2NOS3CYP1A2 | |
| Lysine SCHEMBL27006 | 0.86 | GSR (0.80) | GSRNOS1NOS2NOS3CYP1A2 | |
| Lysine SCHEMBL273455 | 0.86 | GSR (0.80) | GSRNOS1NOS2NOS3CYP1A2 | |
| Lysine SCHEMBL28185340 | 0.86 | GSR (0.80) | GSRNOS1NOS2NOS3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6653432-B2 | Cyclization and trimerization of polyisocyanates in presence of rare earth alcoholate; terminating reaction by deactivation of catalysts; distillation | RHODIA CHIMIE (FR) | 2003-11-25 | — | — | US | disclosed |
| US-20030130467-A1 | Condensation polymerisation method for isocyanates | VENCOREX FRANCE (FR) | 2003-07-10 | — | — | US | disclosed |