SCHEMBL7100072

SCHEMBL7100072

O=C(Nc1ccccc1Cl)c1ccc2cccccc1-2

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 2/20 0.63
CYP1A2 P05177 1/20 0.63
CYP2C19 P33261 1/20 0.63
HTT P42858 1/20 0.61
CHRNB2 P17787 3/20 0.58
CHRNB4 P30926 3/20 0.58
CHRNA3 P32297 3/20 0.58
CHRNA4 P43681 3/20 0.58
MEN1 O00255 2/20 0.52
KMT2A Q03164 2/20 0.52
MAPT P10636 2/20 0.52
NPC1 O15118 2/20 0.52
RAB9A P51151 2/20 0.52
LMNA P02545 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.52
PPARG P37231 1/20 0.51
ALDH1A1 P00352 3/20 0.50
EPHB3 P54753 2/20 0.50
HDAC8 Q9BY41 1/20 0.50
HDAC6 Q9UBN7 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21935717 0.81 TDP1 (0.62) HTTCHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL30887941 0.80 ACLY (0.58) HPGDCYP1A2CYP2C19MEN1KMT2A
SCHEMBL2168262 0.80 ACLY (0.58) HPGDCYP1A2CYP2C19MEN1KMT2A
SCHEMBL31680566 0.79 CYP1A2 (0.89) HPGDCYP1A2CYP2C19MEN1KMT2A
SCHEMBL14252928 0.79 MEN1 (0.79) HPGDCYP1A2CYP2C19MEN1KMT2A
SCHEMBL6631304 0.78 CHRNB2 (0.89) HPGDHTTCHRNB2CHRNB4CHRNA3
SCHEMBL2700280 0.77 CYP1A2 (0.77) HPGDCYP1A2CYP2C19KMT2AMAPT
SCHEMBL2272508 0.76 ACLY (0.63) HTTCHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL418103 0.75 SERPINE1 (0.71) HTTCHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL13455818 0.75 RAB9A (0.63) HPGDCYP1A2CYP2C19MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1325006-A2 HETEROCYCLIC COMPOUNDS AS LIGANDS OF THE GABA A? RECEPTOR NEUROGEN CORPORATION (US) 2003-07-09 EP claimed
WO-2002012442-A2 HETEROCYCLIC COMPOUNDS AS LIGANDS OF THE GABAA RECEPTOR NEUROGEN CORPORATION (US) 2002-02-14 WO claimed