Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.37 |
| ▸ | APAF1 | O14727 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7096051 | 0.88 | PPARG (0.43) | PPARGAPAF1 | |
| SCHEMBL7103133 | 0.87 | AGTR1 (0.39) | PPARGTBXA2RALOX5APAPAF1MEN1 | |
| SCHEMBL7100218 | 0.87 | KDM4E (0.39) | BACE1PPARGKDM4EALOX5APAPAF1 | |
| SCHEMBL7102086 | 0.87 | APAF1 (0.47) | KDM4EAPAF1ALDH1A1MEN1KMT2A | |
| SCHEMBL7096854 | 0.85 | APAF1 (0.39) | PPARGAPAF1 | |
| SCHEMBL7097769 | 0.84 | KMT2A (0.44) | ALDH1A1MEN1KMT2A | |
| SCHEMBL7097958 | 0.82 | PPARG (0.38) | PPARGPPARAALDH1A1MEN1KMT2A | |
| SCHEMBL6426492 | 0.82 | APAF1 (0.40) | TDP1KDM4EAPAF1ALDH1A1MEN1 | |
| SCHEMBL7100556 | 0.81 | MAPT (0.39) | PPARGKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL7098112 | 0.81 | AGTR1 (0.41) | APAF1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326864-A2 | ARYL OR HETEROARYL FUSED IMIDAZOLE COMPOUNDS AS ANTI-INFLAMMATORY AND ANALGESIC AGENTS | PFIZER PHARMACEUTICALS INC. (JP) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002032900-A2 | ARYL OR HETEROARYL FUSED IMIDAZOLE COMPOUNDS AS ANTI-INFLAMMATORY AND ANALGESIC AGENTS | PFIZER PHARMACEUTICALS INC. (JP) | 2002-04-25 | — | — | WO | disclosed |